” Stem Cells and Regenerative medicine researcher with over a decade of experience in exploring therapeutic potential in cell therapy and stem cell regeneration in the event of radiation insult.
Cell transplantation therapies (such as: iPSC derived Hepatocyte like cells (iHeps), human intestinal organoids (iHIOs), bone marrow and patient derived Hu adipose mesenchymal cells) can be used as a treatment for radio-protection and mitigation of acute and chronic radiation injuries in normal tissue.
My areas of focus and expertise include:
• Generation of, 3D human intestinal organoids (iHIOs) from human iPSCs, adult mouse intestinal enteroids (mEnts) and Colon organoids (mCO) as an ex vivo model to screen radiomitigators. demonstrated that transplantation of these organoids in DSS colitis and Radiation Proctitis (RP) mouse model to engrafted and propogated in injured mouse colon.
• Developed a Radiation Proctitis mouse model in the lab: a. to test small molecules and compounds such as hRspo1-fc as radiomitigators, and b. determine if transplantation of mouse colonoids can alleviate inflammation and fibrosis in the proctitis induced animals
• Investigate if cells (mBM and/or human patient derived Mesenchymal Stem cells) and cell free therapy (Exosomes and Secretomes from these cells) can be used as potential therapies in whole body irradiation (WBI) and partial body irradiation (PBI) mouse model to mitigate radiation
• Transplanted hepatocyte like cells (iHep) derived from iPSCs in hepatic irradiated (HIR) animals to replace depleted host hepatocytes and allow proliferation of engrafted iHep in the presence of a mitogen.
• Presented Basic Science Abstract at the International Congress for Radiation Research Conference (ICRR) at Montral, Canada 2023 titled: “Recombinant Human Rspondin -1-Fc promotes crypt regeneration and alleviates inflammation in the rectum of mice with Radiation Proctitis
• Oral presentation in Basic Science Awarded in the Biology category at the Annual Meeting Scientific Program Committee of the American Society for Radiation Oncology (ASTRO) 2013, titled, “Preparative Hepatic irradiation (HIR) for Transplantation of Human Induced Pluripotent Stem Cell (iPSC)-Derived Hepatocyte-Like Cells (iHep )in Mouse Livers”
• Presented Basic Science Abstract at American Society for Radiation Oncology 2013, titled “Human Induced Pluripotent stem Cells (iPSC) Derived Intestinal Organoids (iHIOs) to Screen Radiation Mitigators”
• Awarded First Prize for Einstein-Montefiore Young Research Investigators Symposium (2012) for “Preparative Hepatic irradiation (HIR) for Transplantation of Human Induced Pluripotent Stem Cell (iPSC)- derived Hepatocyte-Like Cell (iHep) in Mouse Livers”
GRANTS 2014-2016 Received funding from Ruth L. David S. Gothesman Institute for Stem Cell & Regenerative Medicine Research of Albert Einstein College of Medicine, for “Human Induced Pluripotent Stem Cell- Derived Intestinal Organoids (iHIOS) for Regenerative Medicine”
PUBLICATIONS
Barahman M, Zhang W, Harris HY, Aiyer A, Kabarriti R, Kinkhabwala M, Roy-Chowdhury N, Beck AP, Scanlan TS, Roy-Chowdhury J, Asp P, Guha C. Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis. J Hepatol. 2019 Jun;70(6):1170-1179. doi: 10.1016/j.jhep.2019.01.010. Epub 2019 Jan 14. PMID: 30654068; PMCID: PMC6986679.
Mueller E, Drori S, Aiyer A, Yie J, Sarraf P, Chen H, Hauser S, Rosen ED, Ge K, Roeder RG, Spiegelman BM. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem. 2002 Nov 1;277(44):41925-30. doi: 10.1074/jbc.M206950200. Epub 2002 Aug 27. PMID: 12200443.
Mueller E, Smith M, Sarraf P, Kroll T, Aiyer A, Kaufman DS, Oh W, Demetri G, Figg WD, Zhou XP, Eng C, Spiegelman BM, Kantoff PW. Effects of ligand activation of peroxi”