Brett I. Bell is an 2026 graduate of the Albert Einstein College of Medicine MD/PhD program who completed his doctoral thesis in pathology in the Guha lab. He earned his B.A. in Biochemistry and Biology and an M.S. in Chemistry from the University of Pennsylvania in 2018. At Penn, Brett conducted research under the mentorship of Dr. Constantinos Koumenis into the role of Interleukin-6 in acute and delayed gastrointestinal toxicity using a novel mouse model of focal image-guided irradiation.
After joining the Guha lab, Brett studied how the physical characteristics of radiation can alter its’ biological effects. He investigated the impact of radiation energy on hematopoietic, gastrointestinal, and immunologic injury using orthovoltage X-rays and 137Cs γ-rays and identified an energy dependence of RBE using modern preclinical irradiators. In collaboration with the New York Proton Center, Brett studied the effects of pencil beam scanned FLASH proton therapy on gastrointestinal toxicity. Furthermore, Brett coordinated multi-institutional collaborations with the Heidelberger Ionenstrahl Therapiezentrum and Brookhaven National Laboratory to elucidate the immunologic consequences of carbon ion radiotherapy in pancreatic cancer. His thesis research was funded by an NCI Ruth L. Kirschstein National Research Service Award (F30CA278322).
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