Research
Our lab focuses on radiation biology and tumor immunology with the goal of improving outcomes for cancer patients. We work with the full range of ionizing and non-ionizing forms of radiation, including low-intensity focused ultrasound (LOFU), photons, protons, and heavy ion radiation.
Highlighted
Whole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality
Brett I. Bell, Christian Velten, Michael Pennock, Minglei Kang, Kathryn E. Tanaka, ..., Charles B. Simone, Weng-Lang Yang, Wolfgang A. Tomé, Haibo Lin, Chandan Guha
International Journal of Radiation Oncology*Biology*Physics
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01 Feb 2025
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doi:10.1016/j.ijrobp.2024.09.006
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
Justin Vercellino, Beata Małachowska, Shilpa Kulkarni, Brett I. Bell, Shahin Shajahan, ..., Amit K. Verma, Sanchita P. Ghosh, Weng-Lang Yang, Paul S. Frenette, Chandan Guha
Stem Cell Research & Therapy
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29 Apr 2024
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doi:10.1186/s13287-024-03734-z
Thrombopoietin mimetic reduces mouse lung inflammation and fibrosis after radiation by attenuating activated endothelial phenotypes
Jeb English, Sriya Dhanikonda, Kathryn E. Tanaka, Wade Koba, Gary Eichenbaum, Weng-Lang Yang, Chandan Guha
JCI Insight
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08 Nov 2024
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doi:10.1172/jci.insight.181330
Our Published Works
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2025
Whole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality
Brett I. Bell, Christian Velten, Michael Pennock, Minglei Kang, Kathryn E. Tanaka, ..., Charles B. Simone, Weng-Lang Yang, Wolfgang A. Tomé, Haibo Lin, Chandan Guha
International Journal of Radiation Oncology*Biology*Physics
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01 Feb 2025
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doi:10.1016/j.ijrobp.2024.09.006
2024
Stereotactic Body Radiotherapy vs Sorafenib Alone in Hepatocellular Carcinoma
Laura A. Dawson, Kathryn A. Winter, Jennifer J. Knox, Andrew X. Zhu, Sunil Krishnan, ..., Jennifer A. Dorth, Guila Delouya, Anand Swaminath, Jennifer Moughan, Christopher H. Crane
JAMA Oncology
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19 Dec 2024
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doi:10.1001/jamaoncol.2024.5403
Comprehensive functional evaluation of head and neck squamous cell carcinoma with BH3-profiling demonstrates apoptotic competency and therapeutic efficacy of BH3-mimetics
Daniel Li, Andrea Lopez, Nitisha Shrivastava, Wesley Chan, Carlos Thomas, ..., Michael B. Prystowsky, Nicolas F. Schlecht, Chandan Guha, Evripidis Gavathiotis, Thomas J. Ow
Oral Oncology
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01 Dec 2024
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doi:10.1016/j.oraloncology.2024.107069
Thrombopoietin mimetic reduces mouse lung inflammation and fibrosis after radiation by attenuating activated endothelial phenotypes
Jeb English, Sriya Dhanikonda, Kathryn E. Tanaka, Wade Koba, Gary Eichenbaum, Weng-Lang Yang, Chandan Guha
JCI Insight
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08 Nov 2024
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doi:10.1172/jci.insight.181330
Thrombopoietin mimetic therapy alleviates radiation-induced bone marrow vascular injury in a bone marrow transplant mouse model
Hemendra Ghimire, Srideshikan Sargur Madabushi, Justin Vercellino, Jamison Brooks, Darren Zuro, ..., Guy Strome, Gary Eichenbaum, Monzr Al Malki, Chandan Guha, Susanta K. Hui
Frontiers in Oncology
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10 Oct 2024
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doi:10.3389/fonc.2024.1414488
Novel time-synchronized immune-guided partial tumor irradiation: Proof of principle trial
S. Tubin, M.L. Ashdown, M.M. Ahmed, C. Guha, G. Salerno, B. Celedin, B. Trummer, S. Demschar, W. Raunik
Radiotherapy and Oncology
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01 Oct 2024
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doi:10.1016/j.radonc.2024.110442
Validation and reproducibility of in vivo dosimetry for pencil beam scanned FLASH proton treatment in mice
Alex Bookbinder, Balaji Selvaraj, Xingyi Zhao, Yunjie Yang, Brett I. Bell, ..., J. Isabelle Choi, Haibo Lin, Charles B. Simone, Chandan Guha, Minglei Kang
Radiotherapy and Oncology
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01 Sep 2024
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doi:10.1016/j.radonc.2024.110404
FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone
Ioannis I. Verginadis, Anastasia Velalopoulou, Michele M. Kim, Kyle Kim, Ioannis Paraskevaidis, ..., James M. Metz, Amit Maity, Keith A. Cengel, Constantinos Koumenis, Theresa M. Busch
Cold Spring Harbor Laboratory
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11 Jul 2024
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doi:10.1101/2024.07.08.602528
Optimizing GRID and Lattice Spatially Fractionated Radiation Therapy: Innovative Strategies for Radioresistant and Bulky Tumor Management
Mansoor M. Ahmed, Xiaodong Wu, Majid Mohiuddin, Naipy C. Perez, Hualin Zhang, Beatriz E. Amendola, Beata Malachowska, Mohammed Mohiuddin, Chandan Guha
Seminars in Radiation Oncology
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01 Jul 2024
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doi:10.1016/j.semradonc.2024.05.002
Innovations in Physics, Biology and Clinical Translation of Spatially Fractionated and FLASH Radiotherapy
Robert J. Griffin, Chandan Guha
Seminars in Radiation Oncology
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01 Jul 2024
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doi:10.1016/j.semradonc.2024.05.005
Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury
Ermanno Malagola, Alessandro Vasciaveo, Yosuke Ochiai, Woosook Kim, Biyun Zheng, ..., Chandan Guha, Chia-Wei Cheng, Kelley S. Yan, Andrea Califano, Timothy C. Wang
Cell
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01 Jun 2024
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doi:10.1016/j.cell.2024.05.004
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
Justin Vercellino, Beata Małachowska, Shilpa Kulkarni, Brett I. Bell, Shahin Shajahan, ..., Amit K. Verma, Sanchita P. Ghosh, Weng-Lang Yang, Paul S. Frenette, Chandan Guha
Stem Cell Research & Therapy
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29 Apr 2024
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doi:10.1186/s13287-024-03734-z
Synergizing radiation therapy and immunotherapy for curing incurable cancers. Opportunities and challenges.
James W Hodge, Chandan Guha, Jacques Neefjes, James L Gulley
Oncology (Williston Park, N.Y.)
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03 Mar 2024
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pmid:18777956
5th International Symposium on Focused Ultrasound : North Bethesda, MD, USA. 28 August- 1 September 2016
Menashe Zaaroor, Alon Sinai, Dorit Goldsher, Ayelet Eran, Maria Nassar, ..., Kim Butts Pauly, Micheal Lustig, Bryant Svedin, Allison Payne, Dennis Parker
Journal of therapeutic ultrasound
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03 Mar 2024
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pmc:PMC5123388
Defining Minimum Treatment Parameters of Ablative Radiation Therapy in Patients With Hepatocellular Carcinoma: An Expert Consensus
Ted K. Yanagihara, Joel E. Tepper, Andrew M. Moon, Aisling Barry, Meritxell Molla, ..., Jennifer Y. Wo, Sang Min Yoon, Theodore S. Lawrence, Maria Reig, Laura A. Dawson
Practical Radiation Oncology
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01 Mar 2024
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doi:10.1016/j.prro.2023.08.016
Selective Personalized RadioImmunotherapy for Locally Advanced Non–Small-Cell Lung Cancer Trial (SPRINT)
Nitin Ohri, Shruti Jolly, Benjamin T. Cooper, Rafi Kabarriti, William R. Bodner, ..., Rasim A. Gucalp, Enrico Castellucci, Angel Qin, Shirish M. Gadgeel, Balazs Halmos
Journal of Clinical Oncology
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10 Feb 2024
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doi:10.1200/jco.23.00627
The potential role of precision medicine to alleviate racial disparities in prostate, bladder and renal urological cancer care
Kunal K. Sindhu, Zachary Dovey, Marcher Thompson, Anthony D. Nehlsen, Karin A. Skalina, Beata Malachowska, Shaakir Hasan, Chandan Guha, Justin Tang, Lucas Resende Salgado
BJUI Compass
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08 Feb 2024
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doi:10.1002/bco2.323
Characterization of a Diverse Set of Conditionally Reprogrammed Head and Neck Cancer Cell Cultures
Thomas J. Ow, Vikas Mehta, Daniel Li, Carlos Thomas, Nitisha Shrivastava, ..., Stelby Augustine, Michael B. Prystowsky, Shanye Yin, Evripidis Gavathiotis, Chandan Guha
The Laryngoscope
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30 Jan 2024
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doi:10.1002/lary.31236
Patterns of presentation and delivery of care of appendiceal neoplasms in the largest municipal health care delivery system in the United States.
Armaan Ahmed, Jennifer Whittington, Zahra Shafaee
Journal of Clinical Oncology
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20 Jan 2024
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doi:10.1200/jco.2024.42.3_suppl.14
Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration
Zhengyu Jiang, Quin T. Waterbury, Ermanno Malagola, Na Fu, Woosook Kim, ..., Feijing Wu, Chandan Guha, Carrie J. Shawber, Kelley S. Yan, Timothy C. Wang
Cellular and Molecular Gastroenterology and Hepatology
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01 Jan 2024
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doi:10.1016/j.jcmgh.2023.10.007
2023
Haematopoietic stem cell numbers are not solely determined by niche availability
Shoichiro Takeishi, Tony Marchand, Wade R. Koba, Daniel K. Borger, Chunliang Xu, Chandan Guha, Aviv Bergman, Paul S. Frenette, Kira Gritsman, Ulrich Steidl
Cold Spring Harbor Laboratory
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29 Oct 2023
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doi:10.1101/2023.10.28.564559
PEGylated thrombopoietin mimetic, JNJ‑26366821 a novel prophylactic radiation countermeasure for acute radiation injury
Gregory P. Holmes-Hampton, Vidya P. Kumar, Shukla Biswas, Sasha Stone, Neel K. Sharma, Betre Legesse, Justin Vercellino, Chandan Guha, Gary Eichenbaum, Sanchita P. Ghosh
Scientific Reports
·
14 Sep 2023
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doi:10.1038/s41598-023-42443-0
Enhancing Immunogenicity in Metastatic Melanoma: Adjuvant Therapies to Promote the Anti-Tumor Immune Response
Sandra Pelka, Chandan Guha
Biomedicines
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10 Aug 2023
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doi:10.3390/biomedicines11082245
Updates on radiotherapy-immunotherapy combinations: Proceedings of 6
th
annual ImmunoRad conference
Fabiana Gregucci, Sheila Spada, Mary Helen Barcellos-Hoff, Nina Bhardwaj, Charleen Chan Wah Hak, ..., Alexandre Bobard, Sandra Demaria, Lorenzo Galluzzi, Eric Deutsch, Silvia C. Formenti
OncoImmunology
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21 Jun 2023
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doi:10.1080/2162402x.2023.2222560
The role of histone H3 lysine demethylases in glioblastoma
Dejauwne Young, Chandan Guha, Simone Sidoli
Cancer and Metastasis Reviews
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01 Jun 2023
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doi:10.1007/s10555-023-10114-1
Commissioning a 250 MeV research beamline for proton FLASH radiotherapy preclinical experiments
Yunjie Yang, Minglei Kang, Chin‐Cheng Chen, Lei Hu, Francis Yu, ..., Michael Pennock, Wolfgang A. Tome, Chanda Guha, Charles B. Simone, Haibo Lin
Medical Physics
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29 Mar 2023
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doi:10.1002/mp.16364
CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma
Nitisha Shrivastava, Claudia Gutierrez Chavez, Daniel Li, Vikas Mehta, Carlos Thomas, ..., Danielle M. Bottalico, Michael B. Prystowsky, Indranil Basu, Chandan Guha, Thomas J. Ow
Cancers
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28 Mar 2023
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doi:10.3390/cancers15072005
Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human α1-antitrypsin deficiency
Yanfeng Li, Chandan Guha, Patrik Asp, Xia Wang, Tatyana L. Tchaikovskya, ..., David H. Perlmutter, Namita Roy-Chowdhury, Ira J. Fox, Anthony Conway, Jayanta Roy-Chowdhury
Hepatology Communications
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27 Feb 2023
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doi:10.1097/hc9.0000000000000070
Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
Alexandre Ribault, Mohamed Amine Benadjaoud, Claire Squiban, Laurent Arnaud, Coralie Judicone, ..., Romaric Lacroix, Stephane Flamant, Emily I. Chen, Jean-Marc Simon, Radia Tamarat
Scientific Reports
·
04 Feb 2023
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doi:10.1038/s41598-022-21726-y
Establishment of a diverse head and neck squamous cancer cell bank using conditional reprogramming culture methods
Daniel Li, Carlos Thomas, Nitisha Shrivastava, Adam Gersten, Nicholas Gadsden, ..., Robert Burk, Michael B. Prystowsky, Chandan Guha, Vikas Mehta, Thomas J. Ow
Journal of Medical Virology
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10 Jan 2023
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doi:10.1002/jmv.28388
Enhanced Glycolysis Confers Resistance Against Photon but Not Carbon Ion Irradiation in Human Glioma Cell Lines
Mohit Vashishta, Vivek Kumar, Chandan Guha, Xiaodong Wu, Bilikere S Dwarakanath
Cancer Management and Research
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01 Jan 2023
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doi:10.2147/cmar.s385968
2022
Carbon Ion Irradiation Downregulates Notch Signaling in Glioma Cell Lines, Impacting Cell Migration and Spheroid Formation
Vivek Kumar, Mohit Vashishta, Lin Kong, Jiade J. Lu, Xiaodong Wu, Bilikere S. Dwarakanath, Chandan Guha
Cells
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24 Oct 2022
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doi:10.3390/cells11213354
Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease
Srideshikan Sargur Madabushi, Raghda Fouda, Hemendra Ghimire, Amr M. H. Abdelhamid, Ji Eun Lim, ..., Darren Zuro, Joseph Rosenthal, Chandan Guha, Kalpna Gupta, Susanta K. Hui
Frontiers in Oncology
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06 Sep 2022
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doi:10.3389/fonc.2022.969429
Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation
Brett I. Bell, Justin Vercellino, N. Patrik Brodin, Christian Velten, Lalitha S.Y. Nanduri, ..., Laibin Liu, Wolfgang A. Tomé, Weng-Lang Yang, Richard Kolesnick, Chandan Guha
Cancer Research
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03 Aug 2022
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doi:10.1158/0008-5472.can-22-0656
Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
Alexandre Ribault, Mohamed Amine Benadjaoud, Claire Squiban, Laurent Arnaud, Coralie Judicone, ..., Romaric Lacroix, Stephane FLAMANT, Emily I. Chen, Jean-Marc Simon, Radia Tamarat
Research Square Platform LLC
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17 Jun 2022
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doi:10.21203/rs.3.rs-1733631/v1
Using quantitative immunohistochemistry in patients at high risk for hepatocellular cancer
Sobia Zaidi, Richard Amdur, Xiyan Xiang, Herbert Yu, Linda L. Wong, ..., Patricia S. Latham, Kirti Shetty, Chandan Guha, Nancy R. Gough, Lopa Mishra
Genes & Cancer
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06 Jun 2022
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doi:10.18632/genesandcancer.220
Improving Adjuvant Liver-Directed Treatment Recommendations for Unresectable Hepatocellular Carcinoma: An Artificial Intelligence–Based Decision-Making Tool
Allen Mo, Christian Velten, Julie M. Jiang, Justin Tang, Nitin Ohri, ..., Boudewijn Aasman, Madhur Garg, Chandan Guha, N. Patrik Brodin, Rafi Kabarriti
JCO Clinical Cancer Informatics
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01 Jun 2022
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doi:10.1200/cci.22.00024
Mitigation of total body irradiation-induced mortality and hematopoietic injury of mice by a thrombopoietin mimetic (JNJ-26366821)
Vidya P. Kumar, Gregory P. Holmes-Hampton, Shukla Biswas, Sasha Stone, Neel Kamal Sharma, Bernadette Hritzo, Mary Guilfoyle, Gary Eichenbaum, Chandan Guha, Sanchita P. Ghosh
Scientific Reports
·
03 Mar 2022
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doi:10.1038/s41598-022-07426-7
Longitudinal Preclinical Imaging Characterizes Extracellular Drug Accumulation After Radiation Therapy in the Healthy and Leukemic Bone Marrow Vascular Microenvironment
Jamison Brooks, Darren Zuro, Joo Y. Song, Srideshikan Sargur Madabushi, James F. Sanchez, ..., Bihong T. Chen, Kalpna Gupta, Guy Storme, Jerry Froelich, Susanta K Hui
International Journal of Radiation Oncology*Biology*Physics
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01 Mar 2022
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doi:10.1016/j.ijrobp.2021.10.146
A positron emission tomography radiomic signature for distant metastases risk in oropharyngeal cancer patients treated with definitive chemoradiotherapy
N. Patrik Brodin, Christian Velten, Jonathan Lubin, Jeremy Eichler, Shaoyu Zhu, ..., Chandan Guha, Shalom Kalnicki, Wolfgang A. Tomé, Madhur K. Garg, Rafi Kabarriti
Physics and Imaging in Radiation Oncology
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01 Jan 2022
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doi:10.1016/j.phro.2022.02.005
2021
Genome-wide host methylation profiling of anal and cervical carcinoma
Erin M. Siegel, Abidemi Ajidahun, Anders Berglund, Whitney Guerrero, Steven Eschrich, ..., Mark J. Becker, Joseph F. Pizzolato, Christopher H. Crane, Kevin D. Brown, David Shibata
PLOS ONE
·
09 Dec 2021
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doi:10.1371/journal.pone.0260857
Using Statistical Measures and Density Maps Generated From Chest Computed Tomography Scans to Identify and Monitor COVID-19 Cases in Radiation Oncology Rapidly
Marie-Hélène Tomé, Megi Gjini, Shaoyu Zhu, Rafi Kabarriti, Chandan Guha, Madhur K Garg, Wolfgang A Tomé, N. Patrik Brodin
Cureus
·
25 Aug 2021
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doi:10.7759/cureus.17432
Normal Tissue Injury Induced by Photon and Proton Therapies: Gaps and Opportunities
Pataje G. Prasanna, Kamila Rawojc, Chandan Guha, Jeffrey C. Buchsbaum, Justyna U. Miszczyk, C. Norman Coleman
International Journal of Radiation Oncology*Biology*Physics
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01 Aug 2021
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doi:10.1016/j.ijrobp.2021.02.043
Extracellular Vesicles for the Treatment of Radiation Injuries
Lalitha Sarad Yamini Nanduri, Phaneendra K. Duddempudi, Weng-Lang Yang, Radia Tamarat, Chandan Guha
Frontiers in Pharmacology
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18 May 2021
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doi:10.3389/fphar.2021.662437
Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities
Ariel E. Marciscano, Adriana Haimovitz-Friedman, Percy Lee, Phuoc T. Tran, Wolfgang A. Tomé, ..., Issam El Naqa, Andreas Rimner, Lawrence B. Marks, Silvia C. Formenti, Theodore L. DeWeese
International Journal of Radiation Oncology*Biology*Physics
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01 May 2021
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doi:10.1016/j.ijrobp.2019.02.046
The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies
Vivek Kumar, Mohit Vashishta, Lin Kong, Xiaodong Wu, Jiade J. Lu, Chandan Guha, B. S. Dwarakanath
Frontiers in Cell and Developmental Biology
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22 Apr 2021
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doi:10.3389/fcell.2021.650772
Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?
Sandra Demaria, Chandan Guha, Jonathan Schoenfeld, Zachary Morris, Arta Monjazeb, ..., Seema Gupta, Silvia Chiara Formenti, Bhadrasain Vikram, C Norman Coleman, Mansoor M Ahmed
Journal for ImmunoTherapy of Cancer
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01 Apr 2021
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doi:10.1136/jitc-2020-002038
Using CT-guided stereotactic prostate radiation therapy (CT-SPRT) to assess sustained murine prostate ablation
Ali H. Zahalka, N. Patrik Brodin, Maria Maryanovich, Xizhe Wang, Kara L. Watts, Sandra Pinho, Chandan Guha, Paul S. Frenette
Scientific Reports
·
22 Mar 2021
·
doi:10.1038/s41598-021-86067-8
Who Benefits the Most From Adjuvant Durvalumab After Chemoradiotherapy for Non-small Cell Lung Cancer? An Exploratory Analysis
Nitin Ohri, Balazs Halmos, William R. Bodner, Haiying Cheng, Madhur K. Garg, Rasim Gucalp, Chandan Guha
Practical Radiation Oncology
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01 Mar 2021
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doi:10.1016/j.prro.2020.09.010
Carbon ion triggered immunogenic necroptosis of nasopharyngeal carcinoma cells involving necroptotic inhibitor BCL-x
Cihang Bao, Yun Sun, Bilikere Dwarakanath, Yuanli Dong, Yangle Huang, Xiaodong Wu, Chandan Guha, Lin Kong, Jiade J. Lu
Journal of Cancer
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01 Jan 2021
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doi:10.7150/jca.46316
2020
Association of Addition of Ablative Therapy Following Transarterial Chemoembolization With Survival Rates in Patients With Hepatocellular Carcinoma
Keara English, N. Patrik Brodin, Viswanathan Shankar, Shaoyu Zhu, Nitin Ohri, ..., Milan Kinkhabwala, Shalom Kalnicki, Madhur K. Garg, Chandan Guha, Rafi Kabarriti
JAMA Network Open
·
05 Nov 2020
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doi:10.1001/jamanetworkopen.2020.23942
The Technical and Clinical Implementation of LATTICE Radiation Therapy (LRT)
Xiaodong Wu, Naipy C. Perez, Yi Zheng, Xiaobo Li, Liuqing Jiang, ..., Georges F. Hatoum, Hualin Zhang, Sha X. Chang, Robert J. Griffin, Chandan Guha
Radiation Research
·
16 Oct 2020
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doi:10.1667/rade-20-00066.1
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, ..., Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Radiation Research
·
12 Oct 2020
·
doi:10.1667/rade-20-00211.1
Association of Race and Ethnicity With Comorbidities and Survival Among Patients With COVID-19 at an Urban Medical Center in New York
Rafi Kabarriti, N. Patrik Brodin, Maxim I. Maron, Chandan Guha, Shalom Kalnicki, Madhur K. Garg, Andrew D. Racine
JAMA Network Open
·
25 Sep 2020
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doi:10.1001/jamanetworkopen.2020.19795
Plasma metabolomic profiles in liver cancer patients following stereotactic body radiotherapy
Sylvia S.W. Ng, Gun Ho Jang, Irwin J. Kurland, Yunping Qiu, Chandan Guha, Laura A. Dawson
eBioMedicine
·
01 Sep 2020
·
doi:10.1016/j.ebiom.2020.102973
Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome
Alison Accarie, Bruno l’Homme, Mohamed Amine Benadjaoud, Sai Kiang Lim, Chandan Guha, Marc Benderitter, Radia Tamarat, Alexandra Sémont
Stem Cell Research & Therapy
·
27 Aug 2020
·
doi:10.1186/s13287-020-01887-1
Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy
Robert J. Griffin, Mansoor M. Ahmed, Beatriz Amendola, Oleg Belyakov, Søren M. Bentzen, ..., Marie-Catherine Vozenin, May Abdel-Wahab, James Welsh, Xiaodong Wu, Charles L. Limoli
International Journal of Radiation Oncology*Biology*Physics
·
01 Jul 2020
·
doi:10.1016/j.ijrobp.2020.03.028
Extent of Prior Lung Irradiation and Mortality in COVID-19 Patients With a Cancer History
Rafi Kabarriti, N. Patrik Brodin, Maxim I. Maron, Wolfgang A. Tomé, Balazs Halmos, Chandan Guha, Shalom Kalnicki, Madhur K. Garg, Nitin Ohri
Advances in Radiation Oncology
·
01 Jul 2020
·
doi:10.1016/j.adro.2020.04.028
Reply to Chowdhary et al
Rafi Kabarriti, N. Patrik Brodin, Maxim I. Maron, Wolfgang A. Tomé, Balazs Halmos, Chandan Guha, Shalom Kalnicki, Madhur K. Garg, Nitin Ohri
Advances in Radiation Oncology
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01 Jul 2020
·
doi:10.1016/j.adro.2020.06.020
The thrombopoietin mimetic JNJ-26366821 increases megakaryopoiesis without affecting malignant myeloid proliferation
Diego Adrianzen-Herrera, Gaurav Choudhary, Shanisha Gordon-Mitchell, Nandini Ramachandra, Tushar Bhagat, ..., Weng-Lang Yang, Michelle Mahler, Gary Eichenbaum, Chandan Guha, Amit Verma
Leukemia & Lymphoma
·
24 Jun 2020
·
doi:10.1080/10428194.2020.1775213
Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex
Sarah C. Garrett-Thomson, Aldo Massimi, Elena V. Fedorov, Jeffrey B. Bonanno, Lisa Scandiuzzi, ..., Ronald D. Seidel, James D. Love, Scott J. Garforth, Chandan Guha, Steven C. Almo
PLOS ONE
·
04 Jun 2020
·
doi:10.1371/journal.pone.0233578
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression
Qiaozhi Wei, Fumio Nakahara, Noboru Asada, Dachuan Zhang, Xin Gao, ..., Samuel E. Zimmerman, Jessica C. Mar, Chandan Guha, Wenjun Guo, Paul S. Frenette
Developmental Cell
·
01 Jun 2020
·
doi:10.1016/j.devcel.2020.04.012
Evaluating dosimetric constraints for carbon ion radiotherapy in the treatment of locally advanced pancreatic cancer
Lien-Chun Lin, Guo-Liang Jiang, Nitin Ohri, Zheng Wang, Jiade J. Lu, Madhur Garg, Chandan Guha, Xiaodong Wu
Radiation Oncology
·
07 May 2020
·
doi:10.1186/s13014-020-01515-5
Trials and Tribulations of Radio-Immuno-Oncology
Chandan Guha
Seminars in Radiation Oncology
·
01 Apr 2020
·
doi:10.1016/j.semradonc.2020.01.001
Lymphocyte-Sparing Radiotherapy: The Rationale for Protecting Lymphocyte-rich Organs When Combining Radiotherapy With Immunotherapy
Philippe Lambin, Relinde I.Y. Lieverse, Franziska Eckert, Damiënne Marcus, Cary Oberije, Alexander M.A. van der Wiel, Chandan Guha, Ludwig J. Dubois, Joseph O. Deasy
Seminars in Radiation Oncology
·
01 Apr 2020
·
doi:10.1016/j.semradonc.2019.12.003
Evaluating Dosimetric Constraints for Carbon Ion Radiotherapy in the Treatment of Locally Advanced Pancreatic Cancer
Lien-Chun Lin, Guo-Liang Jiang, Nitin Ohri, Zheng Wang, Jiade Lu, Madhur Garg, Chandan Guha, XIAODONG Wu
Research Square Platform LLC
·
17 Mar 2020
·
doi:10.21203/rs.2.23301/v3
Postablation Modulation after Single High-Dose Radiation Therapy Improves Tumor Control via Enhanced Immunomodulation
Talicia Savage, Sanjay Pandey, Chandan Guha
Clinical Cancer Research
·
14 Feb 2020
·
doi:10.1158/1078-0432.ccr-18-3518
Circulating microRNAs as Biomarkers of Radiation Exposure: A Systematic Review and Meta-Analysis
Beata Małachowska, Bartłomiej Tomasik, Konrad Stawiski, Shilpa Kulkarni, Chandan Guha, Dipanjan Chowdhury, Wojciech Fendler
International Journal of Radiation Oncology*Biology*Physics
·
01 Feb 2020
·
doi:10.1016/j.ijrobp.2019.10.028
Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity
Sri Nandhini Sethuraman, Mohit Pratap Singh, Girish Patil, Shitao Li, Steven Fiering, P. Jack Hoopes, Chandan Guha, Jerry Malayer, Ashish Ranjan
Theranostics
·
01 Jan 2020
·
doi:10.7150/thno.42243
2019
Use of organoids to study regenerative responses to intestinal damage
Sarah E. Blutt, Ophir D. Klein, Mark Donowitz, Noah Shroyer, Chandan Guha, Mary K. Estes
American Journal of Physiology-Gastrointestinal and Liver Physiology
·
01 Dec 2019
·
doi:10.1152/ajpgi.00346.2018
In-situ vaccination using focused ultrasound heating and anti-CD-40 agonistic antibody enhances T-cell mediated local and abscopal effects in murine melanoma
Mohit Pratap Singh, Sri Nandhini Sethuraman, Jerry Ritchey, Steven Fiering, Chandan Guha, Jerry Malayer, Ashish Ranjan
International Journal of Hyperthermia
·
29 Nov 2019
·
doi:10.1080/02656736.2019.1663280
Non-Invasive Targeted Hepatic Irradiation and SPECT/CT Functional Imaging to Study Radiation-Induced Liver Damage in Small Animal Models
Rafi Kabarriti, N. Patrik Brodin, Hillary Yaffe, Mark Barahman, Wade R. Koba, Laibin Liu, Patrik Asp, Wolfgang A. Tomé, Chandan Guha
Cancers
·
15 Nov 2019
·
doi:10.3390/cancers11111796
Correction: Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma
Mark Yarchoan, Parul Agarwal, Augusto Villanueva, Shuyun Rao, Laura Dawson, ..., Elizabeth Jaffee, Chandan Guha, Lopa Mishra, Norman Coleman, Mansoor Ahmed
Cancer Research
·
15 Nov 2019
·
doi:10.1158/0008-5472.can-19-2958
Daily Step Counts: A New Prognostic Factor in Locally Advanced Non-Small Cell Lung Cancer?
Nitin Ohri, Balazs Halmos, William R. Bodner, Haiying Cheng, Chandan Guha, Shalom Kalnicki, Madhur Garg
International Journal of Radiation Oncology*Biology*Physics
·
01 Nov 2019
·
doi:10.1016/j.ijrobp.2019.07.055
Comparing outcomes following total neoadjuvant therapy and following neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancer
Shaoyu Zhu, N. Patrik Brodin, Keara English, Nitin Ohri, Jennifer W. Chuy, ..., Rahul Narang, Shalom Kalnicki, Chandan Guha, Madhur K. Garg, Rafi Kabarriti
EClinicalMedicine
·
01 Nov 2019
·
doi:10.1016/j.eclinm.2019.09.009
Low Intensity Focused Ultrasound (LOFU)-mediated Acoustic Immune Priming and Ablative Radiation Therapy for in situ Tumor Vaccines
Karin A. Skalina, Saurabh Singh, Claudia Gutierrez Chavez, Fernando Macian, Chandan Guha
Scientific Reports
·
29 Oct 2019
·
doi:10.1038/s41598-019-51332-4
Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma
Mark Yarchoan, Parul Agarwal, Augusto Villanueva, Shuyun Rao, Laura A. Dawson, ..., Elizabeth M. Jaffee, Chandan Guha, Lopa Mishra, C. Norman Coleman, Mansoor M. Ahmed
Cancer Research
·
01 Sep 2019
·
doi:10.1158/0008-5472.can-19-0803
Association between neutrophil–lymphocyte ratio, socioeconomic status, and ethnic minority with treatment outcome in hepatocellular carcinoma
Yifei Zhang, N. Patrik Brodin, Nitin Ohri, Santiago Thibaud, Andreas Kaubisch, Milan Kinkhabwala, Madhur Garg, Chandan Guha, Rafi Kabarriti
Hepatology International
·
01 Aug 2019
·
doi:10.1007/s12072-019-09965-0
Human papillomavirus, radiation dose and survival of patients with anal cancer
Rafi Kabarriti, N. Patrik Brodin, Nitin Ohri, Rahul Narang, Renee Huang, Jennifer W. Chuy, Lakshmi N. Rajdev, Shalom Kalnicki, Chandan Guha, Madhur K. Garg
Acta Oncologica
·
08 Jul 2019
·
doi:10.1080/0284186x.2019.1634834
A Quantitative Clinical Decision–Support Strategy Identifying Which Patients With Oropharyngeal Head and Neck Cancer May Benefit the Most From Proton Radiation Therapy
N. Patrik Brodin, Rafi Kabarriti, Mark Pankuch, Clyde B. Schechter, Vinai Gondi, Shalom Kalnicki, Chandan Guha, Madhur K. Garg, Wolfgang A. Tomé
International Journal of Radiation Oncology*Biology*Physics
·
01 Jul 2019
·
doi:10.1016/j.ijrobp.2018.11.039
Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis
Mark Barahman, Wei Zhang, Hillary Yaffe Harris, Anita Aiyer, Rafi Kabarriti, ..., Amanda P. Beck, Thomas S. Scanlan, Jayanta Roy-Chowdhury, Patrik Asp, Chandan Guha
Journal of Hepatology
·
01 Jun 2019
·
doi:10.1016/j.jhep.2019.01.010
Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate
Maher Hanoun, Anna Arnal-Estapé, Maria Maryanovich, Ali H. Zahalka, Sarah K. Bergren, ..., Avigdor Leftin, Patrik N. Brodin, Michael M. Shen, Chandan Guha, Paul S. Frenette
Stem Cell Reports
·
01 Jun 2019
·
doi:10.1016/j.stemcr.2019.04.019
Centers with more therapeutic modalities are associated with improved outcomes for patients with hepatocellular carcinoma
Julie M. Jiang, Nitin Ohri, Justin Tang, Renee Moadel, Jacob Cynamon, Andreas Kaubisch, Milan Kinkhabwala, Madhur K. Garg, Chandan Guha, Rafi Kabarriti
Journal of Gastrointestinal Oncology
·
01 Jun 2019
·
doi:10.21037/jgo.2019.01.30
Hepatocyte Transplantation: Quo Vadis?
Mark Barahman, Patrik Asp, Namita Roy-Chowdhury, Milan Kinkhabwala, Jayanta Roy-Chowdhury, Rafi Kabarriti, Chandan Guha
International Journal of Radiation Oncology*Biology*Physics
·
01 Mar 2019
·
doi:10.1016/j.ijrobp.2018.11.016
BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice
Yoku Hayakawa, Mayo Tsuboi, Samuel Asfaha, Hiroto Kinoshita, Ryota Niikura, ..., Yoshihiro Hirata, Chandan Guha, Kelley S. Yan, Kazuhiko Koike, Timothy C. Wang
Gastroenterology
·
01 Mar 2019
·
doi:10.1053/j.gastro.2018.11.024
Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1
Thomas J. Ow, Cory D. Fulcher, Carlos Thomas, Pilib Ó Broin, Andrea López, ..., Thomas M. Harris, Geoffrey C. Childs, Nicole Kawachi, Chandan Guha, Evripidis Gavathiotis
Oncotarget
·
11 Jan 2019
·
doi:10.18632/oncotarget.26563
Origin of Locoregional Recurrences After Definitive Intensity-modulated Radiation Therapy (IMRT) for Laryngeal Cancer Determined Based on Follow-up PET/CT Imaging
Rafi Kabarriti, N. Patrik Brodin, Sadia Ahmed, Ivan Vogelius, Chandan Guha, Shalom Kalnicki, Wolfgang A Tomé, Madhur K Garg
Cureus
·
08 Jan 2019
·
doi:10.7759/cureus.3856
2018
Radiation therapy for patients with newly diagnosed metastatic head and neck squamous cell carcinoma
Rafi Kabarriti, Sujith Baliga, Nitin Ohri, Chandan Guha, Shalom Kalnicki, Madhur K. Garg
Head & Neck
·
16 Dec 2018
·
doi:10.1002/hed.25476
Model for End-Stage Liver Disease and Sodium Velocity Predicts Overall Survival in Nonmetastatic Hepatocellular Carcinoma Patients
Justin Y. Tang, Nitin Ohri, Rafi Kabarriti, Santiago Aparo, Jennifer Chuy, Sanjay Goel, Jonathan M. Schwartz, Milan Kinkhabwala, Andreas Kaubisch, Chandan Guha
Canadian Journal of Gastroenterology and Hepatology
·
07 Nov 2018
·
doi:10.1155/2018/5681979
Utilization of Transoral Robotic Surgery (TORS) in patients with Oropharyngeal Squamous Cell Carcinoma and its impact on survival and use of chemotherapy
Sujith Baliga, Rafi Kabarriti, Julie Jiang, Vikas Mehta, Chandan Guha, Shalom Kalnicki, Richard V. Smith, Madhur K. Garg
Oral Oncology
·
01 Nov 2018
·
doi:10.1016/j.oraloncology.2018.06.009
Radiofrequency Ablation Versus Stereotactic Body Radiotherapy for Hepatocellular Carcinoma: Caution When Interpreting Observational Data
Nitin Ohri, Rafi Kabarriti, Andreas Kaubisch, Chandan Guha
Journal of Clinical Oncology
·
20 Aug 2018
·
doi:10.1200/jco.2018.78.0122
Therapeutic potential of adenovirus-mediated TFF2-CTP-Flag peptide for treatment of colorectal cancer
Zinaida A. Dubeykovskaya, Phaneendra Kumar Duddempudi, Huan Deng, Giovanni Valenti, Krystle L. Cuti, Karan Nagar, Yagnesh Tailor, Chandan Guha, Jan Kitajewski, Timothy C. Wang
Cancer Gene Therapy
·
25 Jul 2018
·
doi:10.1038/s41417-018-0036-z
Systematic Review of Normal Tissue Complication Models Relevant to Standard Fractionation Radiation Therapy of the Head and Neck Region Published After the QUANTEC Reports
N. Patrik Brodin, Rafi Kabarriti, Madhur K. Garg, Chandan Guha, Wolfgang A. Tomé
International Journal of Radiation Oncology*Biology*Physics
·
01 Feb 2018
·
doi:10.1016/j.ijrobp.2017.09.041
2017
Expression of the DNA repair gene MLH1 correlates with survival in patients who have resected pancreatic cancer and have received adjuvant chemoradiation: NRG Oncology RTOG Study 9704
Yaacov R. Lawrence, Jennifer Moughan, Anthony M. Magliocco, Alexander C. Klimowicz, William F. Regine, ..., Talia Golan, Kathryn A. Winter, Chandan Guha, Christopher H. Crane, Adam P. Dicker
Cancer
·
20 Oct 2017
·
doi:10.1002/cncr.31058
Host conditioning and rejection monitoring in hepatocyte transplantation in humans
Kyle A. Soltys, Kentaro Setoyama, Edgar N. Tafaleng, Alejandro Soto Gutiérrez, Jason Fong, ..., Marilia Cascalho, Chandan Guha, Rakesh Sindhi, Jeffrey L. Platt, Ira J. Fox
Journal of Hepatology
·
01 May 2017
·
doi:10.1016/j.jhep.2016.12.017
MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa
Selamawit Tadesse, Georgia Corner, Elena Dhima, Michele Houston, Chandan Guha, Leonard Augenlicht, Anna Velcich
Oncotarget
·
06 Apr 2017
·
doi:10.18632/oncotarget.16886
Continuous Activity Monitoring During Concurrent Chemoradiotherapy
Nitin Ohri, Rafi Kabarriti, William R. Bodner, Keyur J. Mehta, Viswanathan Shankar, ..., Missak Haigentz, Bruce Rapkin, Chandan Guha, Shalom Kalnicki, Madhur Garg
International Journal of Radiation Oncology*Biology*Physics
·
01 Apr 2017
·
doi:10.1016/j.ijrobp.2016.12.030
Significance of Co-expression of Epidermal Growth Factor Receptor and Ki67 on Clinical Outcome in Patients With Anal Cancer Treated With Chemoradiotherapy: An Analysis of NRG Oncology RTOG 9811
Corinne M. Doll, Jennifer Moughan, Alexander Klimowicz, Clement K. Ho, Elizabeth N. Kornaga, ..., Robert J. Ellis, Paul W. Sperduto, Gerald W. Marsa, Chandan Guha, Anthony M. Magliocco
International Journal of Radiation Oncology*Biology*Physics
·
01 Mar 2017
·
doi:10.1016/j.ijrobp.2016.11.021
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy
Eszter Lázár-Molnár, Lisa Scandiuzzi, Indranil Basu, Thomas Quinn, Eliezer Sylvestre, Edith Palmieri, Udupi A. Ramagopal, Stanley G. Nathenson, Chandan Guha, Steven C. Almo
EBioMedicine
·
01 Mar 2017
·
doi:10.1016/j.ebiom.2017.02.004
Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates
Wojciech Fendler, Beata Malachowska, Khyati Meghani, Panagiotis A. Konstantinopoulos, Chandan Guha, Vijay K. Singh, Dipanjan Chowdhury
Science Translational Medicine
·
01 Mar 2017
·
doi:10.1126/scitranslmed.aal2408
A Model for Precise and Uniform Pelvic- and Limb-Sparing Abdominal Irradiation to Study the Radiation-Induced Gastrointestinal Syndrome in Mice Using Small Animal Irradiation Systems
N. Patrik Brodin, Anna Velcich, Chandan Guha, Wolfgang A. Tomé
Dose-Response
·
04 Jan 2017
·
doi:10.1177/1559325816685798
2016
Human Urinary Epithelial Cells as a Source of Engraftable Hepatocyte-Like Cells Using Stem Cell Technology
Vanessa Sauer, Tatyana Tchaikovskaya, Xia Wang, Yanfeng Li, Wei Zhang, ..., Jianqiang Ding, Chandan Guha, Ira J. Fox, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury
Cell Transplantation
·
01 Dec 2016
·
doi:10.3727/096368916x692014
Gunn Rats as a Surrogate Model for Evaluation of Hepatocyte Transplantation-Based Therapies of Crigler–Najjar Syndrome Type 1
Zsuzsanna Polgar, Yanfeng Li, Xia Li Wang, Chandan Guha, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury
Methods in Molecular Biology
·
10 Nov 2016
·
doi:10.1007/978-1-4939-6506-9_9
Identifying Urinary and Serum Exosome Biomarkers for Radiation Exposure Using a Data Dependent Acquisition and SWATH-MS Combined Workflow
Shilpa Kulkarni, Antonius Koller, Kartik M. Mani, Ruofeng Wen, Alan Alfieri, ..., Jian Wang, Purvi Patel, Nuno Bandeira, Chandan Guha, Emily I. Chen
International Journal of Radiation Oncology*Biology*Physics
·
01 Nov 2016
·
doi:10.1016/j.ijrobp.2016.06.008
Precision Medicine and Pancreatic Cancer
James J. Farrell, Jennifer Moughan, Jonathan L. Wong, William F. Regine, Paul Schaefer, ..., Raymond Lai, Zhong Zheng, Gerold Bepler, Chandan Guha, Hany Elsaleh
Pancreas
·
01 Nov 2016
·
doi:10.1097/mpa.0000000000000710
Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
Subhrajit Saha, Evelyn Aranda, Yoku Hayakawa, Payel Bhanja, Safinur Atay, ..., Andrew K. Godwin, Wolfgang A. Tome, Timothy C. Wang, Chandan Guha, Jeffrey W. Pollard
Nature Communications
·
13 Oct 2016
·
doi:10.1038/ncomms13096
Targeted Therapy for Hepatocellular Carcinoma
Nitin Ohri, Andreas Kaubisch, Madhur Garg, Chandan Guha
Seminars in Radiation Oncology
·
01 Oct 2016
·
doi:10.1016/j.semradonc.2016.06.004
Stromal Progenitor Cells in Mitigation of Non-hematopoietic Radiation Injuries
Shilpa Kulkarni, Timothy C. Wang, Chandan Guha
Current Pathobiology Reports
·
07 Sep 2016
·
doi:10.1007/s40139-016-0114-6
Hepatocyte-like cells derived from induced pluripotent stem cells
Namita Roy-Chowdhury, Xia Wang, Chandan Guha, Jayanta Roy-Chowdhury
Hepatology International
·
17 Aug 2016
·
doi:10.1007/s12072-016-9757-y
Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia
Lohith Bachegowda, Kerry Morrone, Shannon L. Winski, Ioannis Mantzaris, Matthias Bartenstein, ..., Leonidas C. Platanias, Laurence E. Burgess, Kith Pradhan, Ulrich Steidl, Amit Verma
Cancer Research
·
14 Aug 2016
·
doi:10.1158/0008-5472.can-15-3062
Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study
Nitin Ohri, Laura A. Dawson, Sunil Krishnan, Jinsil Seong, Jason C. Cheng, ..., Milan Kinkhabwala, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Chandan Guha
Journal of the National Cancer Institute
·
04 Jul 2016
·
doi:10.1093/jnci/djw133
Radiation Therapy Noncompliance and Clinical Outcomes in an Urban Academic Cancer Center
Nitin Ohri, Bruce D. Rapkin, Chandan Guha, Shalom Kalnicki, Madhur Garg
International Journal of Radiation Oncology*Biology*Physics
·
01 Jun 2016
·
doi:10.1016/j.ijrobp.2016.01.043
Tumor Cells Surviving Exposure to Proton or Photon Radiation Share a Common Immunogenic Modulation Signature, Rendering Them More Sensitive to T Cell–Mediated Killing
Sofia R. Gameiro, Anthony S. Malamas, Michael B. Bernstein, Kwong Y. Tsang, April Vassantachart, ..., Rajesh Pidikiti, Chandan P. Guha, Stephen M. Hahn, Sunil Krishnan, James W. Hodge
International Journal of Radiation Oncology*Biology*Physics
·
01 May 2016
·
doi:10.1016/j.ijrobp.2016.02.022
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling
Sai Krishna Athuluri-Divakar, Rodrigo Vasquez-Del Carpio, Kaushik Dutta, Stacey J. Baker, Stephen C. Cosenza, ..., Peter K. Vogt, David Mulholland, Chandan Guha, Aneel K. Aggarwal, E. Premkumar Reddy
Cell
·
01 Apr 2016
·
doi:10.1016/j.cell.2016.03.045
RECQ1 A159C Polymorphism Is Associated With Overall Survival of Patients With Resected Pancreatic Cancer: A Replication Study in NRG Oncology Radiation Therapy Oncology Group 9704
Donghui Li, Jennifer Moughan, Christopher Crane, John P. Hoffman, William F. Regine, ..., Ping Chang, Gary M. Freedman, Kathryn A. Winter, Chandan Guha, James L. Abbruzzese
International Journal of Radiation Oncology*Biology*Physics
·
01 Mar 2016
·
doi:10.1016/j.ijrobp.2015.10.062
Do changes in interfraction organ at risk volume and cylinder insertion geometry impact delivered dose in high-dose-rate vaginal cuff brachytherapy?
Shyamal Patel, Keyur J. Mehta, Hsiang-Chi G. Kuo, Nitin Ohri, Rajal Patel, Ravi Yaparpalvi, Madhur K. Garg, Chandan Guha, Shalom Kalnicki
Brachytherapy
·
01 Mar 2016
·
doi:10.1016/j.brachy.2015.11.004
In Vitro Photoirradiation System for Simultaneous Irradiation with Different Light Doses at a Fixed Temperature
Luis F. Hernández Quintanar, Fulgencio Y. López Silva, Diego A. Fabila Bustos, Joel Serrano Navarro, José M. de La Rosa Vázquez, Patrik N. Brodin, Chandan Guha, Wolfgang A. Tomé, Suren Stolik Isakina
Photomedicine and Laser Surgery
·
01 Mar 2016
·
doi:10.1089/pho.2015.4030
Management algorithm for HIV-associated parotid lymphoepithelial cysts
Waleed F. Mourad, Shyamal Patel, Rebekah Young, Azita S. Khorsandi, Catherine Concert, ..., Chandan Guha, Madhur K. Garg, Kenneth S. Hu, Shalom Kalnicki, Louis B. Harrison
European Archives of Oto-Rhino-Laryngology
·
16 Feb 2016
·
doi:10.1007/s00405-016-3926-4
Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape
Sanmay Bandyopadhyay, Thomas J. Quinn, Lisa Scandiuzzi, Indranil Basu, Ari Partanen, Wolfgang A. Tomé, Fernando Macian, Chandan Guha
The Journal of Immunology
·
15 Feb 2016
·
doi:10.4049/jimmunol.1500541
A simple method for determining the coagulation threshold temperature of transparent tissue‐mimicking thermal therapy gel phantoms: Validated by magnetic resonance imaging thermometry
N. Patrik Brodin, Ari Partanen, Patrik Asp, Craig A. Branch, Chandan Guha, Wolfgang A. Tomé
Medical Physics
·
08 Feb 2016
·
doi:10.1118/1.4941361
Dosimetry Formalism and Implementation of a Homogenous Irradiation Protocol to Improve the Accuracy of Small Animal Whole-Body Irradiation Using a 137Cs Irradiator
N. Patrik Brodin, Yong Chen, Ravindra Yaparpalvi, Chandan Guha, Wolfgang A. Tomé
Health Physics
·
01 Feb 2016
·
doi:10.1097/hp.0000000000000462
Hippocampal-dependent neurocognitive impairment following cranial irradiation observed in pre-clinical models: current knowledge and possible future directions
Wolfgang A Tomé, Şölen Gökhan, Maria E Gulinello, N Patrik Brodin, John Heard, Mark F Mehler, Chandan Guha
The British Journal of Radiology
·
01 Jan 2016
·
doi:10.1259/bjr.20150762
2015
Glycogen Synthase Kinase 3 Beta Predicts Survival in Resected Adenocarcinoma of the Pancreas
Edgar Ben-Josef, Asha George, William F. Regine, Ross Abrams, Meredith Morgan, ..., Samir Narayan, Kathryn Winter, Kent A. Griffith, Chandan Guha, Terence M. Williams
Clinical Cancer Research
·
14 Dec 2015
·
doi:10.1158/1078-0432.ccr-15-0789
Proposal for a Simple and Efficient Monthly Quality Management Program Assessing the Consistency of Robotic Image-Guided Small Animal Radiation Systems
N. Patrik Brodin, Chandan Guha, Wolfgang A. Tomé
Health Physics
·
01 Nov 2015
·
doi:10.1097/hp.0000000000000323
In vivo1H MRS and31P MRSI of the response to cyclocreatine in transgenic mouse liver expressing creatine kinase
Min-Hui Cui, Kamaiah Jayalakshmi, Laibin Liu, Chandan Guha, Craig A. Branch
NMR in Biomedicine
·
09 Oct 2015
·
doi:10.1002/nbm.3391
A mouse model replicating hippocampal sparing cranial irradiation in humans: A tool for identifying new strategies to limit neurocognitive decline
Wolfgang A. Tomé, Şölen Gökhan, N. Patrik Brodin, Maria E. Gulinello, John Heard, Mark F. Mehler, Chandan Guha
Scientific Reports
·
24 Sep 2015
·
doi:10.1038/srep14384
Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes
Yong Chen, Yanfeng Li, Xia Wang, Wei Zhang, Vanessa Sauer, ..., Eric E. Bouhassira, Chandan Guha, Ira J. Fox, Jayanta Roy-Chowdhury, Namita Roy-Chowdhury
Stem Cell Reports
·
01 Jul 2015
·
doi:10.1016/j.stemcr.2015.04.017
Are We Ready for a Radiological Terrorist Attack Yet? Report From the Centers for Medical Countermeasures Against Radiation Network
David J. Brenner, Nelson J. Chao, Joel S. Greenberger, Chandan Guha, William H. McBride, Harold M. Swartz, Jacqueline P. Williams
International Journal of Radiation Oncology*Biology*Physics
·
01 Jul 2015
·
doi:10.1016/j.ijrobp.2015.02.042
Investigation of the stress response to mechanical versus thermal non-ablative focused ultrasound therapy in three in vivo murine cancer models
Steffie Peters, Karin Skalina, Lisa Scandiuzzi, Ari Partanen, Holger Grüll, Chandan Guha
Journal of Therapeutic Ultrasound
·
30 Jun 2015
·
doi:10.1186/2050-5736-3-s1-p71
Immunomodulation of prostate cancer cells after low energy focused ultrasound
Karin Skalina, Huagang Zhang, Lisa Scandiuzzi, Indranil Basu, Chandan Guha
Journal of Therapeutic Ultrasound
·
30 Jun 2015
·
doi:10.1186/2050-5736-3-s1-o63
Integrative Metabolic Signatures for Hepatic Radiation Injury
Irwin Jack Kurland, Pilib Ó. Broin, Aaron Golden, Gang Su, Fan Meng, Laibin Liu, Robert Mohney, Shilpa Kulkarni, Chandan Guha
PLOS ONE
·
05 Jun 2015
·
doi:10.1371/journal.pone.0124795
Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury
Sanket S. Acharya, Wojciech Fendler, Jacqueline Watson, Abigail Hamilton, Yunfeng Pan, ..., Payel Bhanja, Subhrajit Saha, Chandan Guha, Kalindi Parmar, Dipanjan Chowdhury
Science Translational Medicine
·
13 May 2015
·
doi:10.1126/scitranslmed.aaa6593
The Triterpenoid RTA 408 is a Robust Mitigator of Hematopoietic Acute Radiation Syndrome in Mice
Devorah C. Goldman, Vitali Alexeev, Elizabeth Lash, Chandan Guha, Ulrich Rodeck, William H. Fleming
Radiation Research
·
01 Mar 2015
·
doi:10.1667/rr13900.1
Intestinal Microbiota-Derived Metabolomic Blood Plasma Markers for Prior Radiation Injury
Pilib Ó Broin, Bhavapriya Vaitheesvaran, Subhrajit Saha, Kirsten Hartil, Emily I. Chen, Devorah Goldman, William Harv Fleming, Irwin J. Kurland, Chandan Guha, Aaron Golden
International Journal of Radiation Oncology*Biology*Physics
·
01 Feb 2015
·
doi:10.1016/j.ijrobp.2014.10.023
Pre-treatment FDG-PET predicts the site of in-field progression following concurrent chemoradiotherapy for stage III non-small cell lung cancer
Nitin Ohri, Bilal Piperdi, Madhur K. Garg, William R. Bodner, Rasim Gucalp, Roman Perez-Soler, Steven M. Keller, Chandan Guha
Lung Cancer
·
01 Jan 2015
·
doi:10.1016/j.lungcan.2014.10.016
Predictors of Radiation Therapy Noncompliance in an Urban Academic Cancer Center
Nitin Ohri, Bruce D. Rapkin, Debayan Guha, Hilda Haynes-Lewis, Chandan Guha, Shalom Kalnicki, Madhur Garg
International Journal of Radiation Oncology*Biology*Physics
·
01 Jan 2015
·
doi:10.1016/j.ijrobp.2014.09.030
2014
Photodynamic Therapy and Its Role in Combined Modality Anticancer Treatment
N. Patrik Brodin, Chandan Guha, Wolfgang A. Tomé
Technology in Cancer Research & Treatment
·
05 Nov 2014
·
doi:10.1177/1533034614556192
Prostate-specific antigen decline during salvage radiation therapy following prostatectomy is associated with reduced biochemical failure
Rafi Kabarriti, Nitin Ohri, Raquibul Hannan, Nima Tishbi, Sujith Baliga, ..., Waleed F. Mourad, Reza Ghavamian, Shalom Kalnicki, Chandan Guha, Madhur K. Garg
Practical Radiation Oncology
·
01 Nov 2014
·
doi:10.1016/j.prro.2014.01.002
Contouring and Constraining Bowel on a Full-Bladder Computed Tomography Scan May Not Reflect Treatment Bowel Position and Dose Certainty in Gynecologic External Beam Radiation Therapy
Ravindra Yaparpalvi, Keyur J. Mehta, Michael B. Bernstein, Rafi Kabarriti, Linda X. Hong, Madhur K. Garg, Chandan Guha, Shalom Kalnicki, Wolfgang A. Tomé
International Journal of Radiation Oncology*Biology*Physics
·
01 Nov 2014
·
doi:10.1016/j.ijrobp.2014.07.016
An AutologousIn SituTumor Vaccination Approach for Hepatocellular Carcinoma. 1. Flt3 Ligand Gene Transfer Increases Antitumor Effects of a Radio-Inducible Suicide Gene Therapy in an Ectopic Tumor Model
Yujo Kawashita, Niloy J. Deb, Madhur Garg, Rafi Kabarriti, Alan Alfieri, Masahiko Takahashi, Jayanta Roy-Chowdhury, Chandan Guha
Radiation Research
·
01 Aug 2014
·
doi:10.1667/rr13594.1
Immunobiology of Radiotherapy: New Paradigms
Mansoor M. Ahmed, Chandan Guha, James W. Hodge, Elizabeth Jaffee
Radiation Research
·
01 Aug 2014
·
doi:10.1667/rr13849.1
Considerations for Combined Immune Checkpoint Modulation and Radiation Treatment
Steven C. Almo, Chandan Guha
Radiation Research
·
01 Aug 2014
·
doi:10.1667/rr13667.1
Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects
Marc Benderitter, Fabio Caviggioli, Alain Chapel, Robert P. Coppes, Chandan Guha, ..., Olivier Malard, Fiona Stewart, Radia Tamarat, Peter van Luijk, Charles L. Limoli
Antioxidants & Redox Signaling
·
10 Jul 2014
·
doi:10.1089/ars.2013.5652
An Autologous In Situ Tumor Vaccination Approach for Hepatocellular Carcinoma. 2. Tumor-Specific Immunity and Cure after Radio-Inducible Suicide Gene Therapy and Systemic CD40-Ligand and Flt3-Ligand Gene Therapy in an Orthotopic Tumor Model
Yujo Kawashita, Niloy J. Deb, Madhur K. Garg, Rafi Kabarriti, Zuoheng Fan, Alan A. Alfieri, Jayanta Roy-Chowdhury, Chandan Guha
Radiation Research
·
03 Jul 2014
·
doi:10.1667/rr13617.1
Bone Marrow–Derived Stromal Cell Therapy in Cirrhosis: Clinical Evidence, Cellular Mechanisms, and Implications for the Treatment of Hepatocellular Carcinoma
Jeffrey M. Vainshtein, Rafi Kabarriti, Keyur J. Mehta, Jayanta Roy-Chowdhury, Chandan Guha
International Journal of Radiation Oncology*Biology*Physics
·
01 Jul 2014
·
doi:10.1016/j.ijrobp.2014.02.017
Low intensity focused ultrasound (LOFU) modulates unfolded protein response and sensitizes prostate cancer to 17AAG
Subhrajit Saha, Payel Bhanja, Ari Partanen, Wei Zhang, Laibin Liu, Wolfgang A. Tomé, Chandan Guha
Oncoscience
·
03 Jun 2014
·
doi:10.18632/oncoscience.48
Advanced mass spectrometry‐based multi‐omics technologies for exploring the pathogenesis of hepatocellular carcinoma
Wenna Nie, Leyu Yan, Yie H. Lee, Chandan Guha, Irwin J. Kurland, Haitao Lu
Mass Spectrometry Reviews
·
02 Jun 2014
·
doi:10.1002/mas.21439
Hedgehog signaling and radiation induced liver injury: a delicate balance
Rafi Kabarriti, Chandan Guha
Hepatology International
·
08 May 2014
·
doi:10.1007/s12072-014-9532-x
Radiation-Induced Modulation of Costimulatory and Coinhibitory T-Cell Signaling Molecules on Human Prostate Carcinoma Cells Promotes Productive Antitumor Immune Interactions
Michael B. Bernstein, Charlie T. Garnett, Huogang Zhang, Anna Velcich, Max M. Wattenberg, Sofia R. Gameiro, Shalom Kalnicki, James W. Hodge, Chandan Guha
Cancer Biotherapy and Radiopharmaceuticals
·
01 May 2014
·
doi:10.1089/cbr.2013.1578
Rigosertib Is a More Effective Radiosensitizer Than Cisplatin in Concurrent Chemoradiation Treatment of Cervical Carcinoma, In Vitro and In Vivo
Lorenzo Agoni, Indranil Basu, Seema Gupta, Alan Alfieri, Angela Gambino, Gary L. Goldberg, E. Premkumar Reddy, Chandan Guha
International Journal of Radiation Oncology*Biology*Physics
·
01 Apr 2014
·
doi:10.1016/j.ijrobp.2013.12.051
Liver regeneration and energetic changes in rats following hepatic radiation therapy and hepatocyte transplantation by 31P MRSI
Charles S. Landis, Hongchao Zhou, Laibin Liu, Hoby P. Hetherington, Chandan Guha
Liver International
·
15 Mar 2014
·
doi:10.1111/liv.12507
A Nonhuman Primate Model of Human Radiation-Induced Venocclusive Liver Disease and Hepatocyte Injury
Govardhana Rao Yannam, Bing Han, Kentaro Setoyama, Toshiyuki Yamamoto, Ryotaro Ito, ..., Charles A. Enke, Janina Baranowska-Kortylewicz, Timothy D. Solberg, Chandan Guha, Ira J. Fox
International Journal of Radiation Oncology*Biology*Physics
·
01 Feb 2014
·
doi:10.1016/j.ijrobp.2013.10.037
Induced Pluripotent Stem Cells as a Source of Hepatocytes
Vanessa Sauer, Namita Roy-Chowdhury, Chandan Guha, Jayanta Roy-Chowdhury
Current Pathobiology Reports
·
11 Jan 2014
·
doi:10.1007/s40139-013-0039-2
Biological Effects Induced by Non-thermal Ultrasound and Implications for Cancer Therapy
Justin Tang, Chandan Guha, Wolfgang A. Tomé
Technology in Cancer Research & Treatment
·
01 Jan 2014
·
doi:10.7785/tcrt.2012.500407
2013
Construction of liver tissue in vivo with preparative partial hepatic irradiation and growth stimulus: investigations of less invasive techniques and progenitor cells
Kensuke Miyazaki, Kosho Yamanouchi, Yusuke Sakai, Izumi Yamaguchi, Mitsuhisa Takatsuki, Tamotsu Kuroki, Chandan Guha, Susumu Eguchi
Journal of Surgical Research
·
01 Dec 2013
·
doi:10.1016/j.jss.2013.06.016
Lessons Learned from Radiation Oncology Clinical Trials
Fei-Fei Liu, Paul Okunieff, Eric J. Bernhard, Helen B. Stone, Stephen Yoo, C. Norman Coleman, Bhadrasain Vikram, Martin Brown, John Buatti, Chandan Guha
Clinical Cancer Research
·
14 Nov 2013
·
doi:10.1158/1078-0432.ccr-13-1116
Endothelial cells mitigate DNA damage and promote the regeneration of hematopoietic stem cells after radiation injury
Derek K. Zachman, Ronald P. Leon, Prerna Das, Devorah C. Goldman, Kimberly L. Hamlin, Chandan Guha, William H. Fleming
Stem Cell Research
·
01 Nov 2013
·
doi:10.1016/j.scr.2013.07.001
Harnessing the Potential of Radiation-Induced Immune Modulation for Cancer Therapy
Mansoor M. Ahmed, James W. Hodge, Chandan Guha, Eric J. Bernhard, Bhadrasain Vikram, C. Norman Coleman
Cancer Immunology Research
·
01 Nov 2013
·
doi:10.1158/2326-6066.cir-13-0141
Variant Splicing and Influence of Ionizing Radiation on Human Endogenous Retrovirus K (HERV-K) Transcripts in Cancer Cell Lines
Lorenzo Agoni, Jack Lenz, Chandan Guha
PLoS ONE
·
18 Oct 2013
·
doi:10.1371/journal.pone.0076472
Combination Therapy with Local Radiofrequency Ablation and Systemic Vaccine Enhances Antitumor Immunity and Mediates Local and Distal Tumor Regression
Sofia R. Gameiro, Jack P. Higgins, Matthew R. Dreher, David L. Woods, Goutham Reddy, Bradford J. Wood, Chandan Guha, James W. Hodge
PLoS ONE
·
24 Jul 2013
·
doi:10.1371/journal.pone.0070417
Clinical and molecular exploration of the impact of radiation therapy on Marfan syndrome patients
Dukagjin M. Blakaj, Hua-Gang Zhang, Adriana Blakaj, Waleed F. Mourad, Belinda Clarke, Marnee Spierer, Shalom Kalnicki, Chandan Guha
Practical Radiation Oncology
·
01 Jul 2013
·
doi:10.1016/j.prro.2012.07.006
Who Benefits From Adjuvant Radiation Therapy for Gastric Cancer? A Meta-Analysis
Nitin Ohri, Madhur K. Garg, Santiago Aparo, Andreas Kaubisch, Wolfgang Tome, Timothy J. Kennedy, Shalom Kalnicki, Chandan Guha
International Journal of Radiation Oncology*Biology*Physics
·
01 Jun 2013
·
doi:10.1016/j.ijrobp.2013.02.008
Effects of radiation on the epidermal growth factor receptor pathway in the heart
Vijayalakshmi Sridharan, Sunil K. Sharma, Eduardo G. Moros, Peter M. Corry, Preeti Tripathi, Benjamin J. Lieblong, Chandan Guha, Martin Hauer-Jensen, Marjan Boerma
International Journal of Radiation Biology
·
16 Apr 2013
·
doi:10.3109/09553002.2013.782110
Opportunities and Challenges in the Era of Molecularly Targeted Agents and Radiation Therapy
Steven H. Lin, Thomas J. George, Edgar Ben-Josef, Jeffrey Bradley, Kevin S. Choe, ..., Meng X. Welliver, C. Norman Coleman, Bhadrasain Vikram, Stephen Yoo, Christine H. Chung
JNCI: Journal of the National Cancer Institute
·
15 Mar 2013
·
doi:10.1093/jnci/djt055
T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice
Arun Gupta, Clayton R. Hunt, Raj K. Pandita, Juhee Pae, K. Komal, ..., Nobuo Horikoshi, Walter N. Hittelman, Chandan Guha, Thomas Ludwig, Tej K. Pandita
Mutagenesis
·
05 Feb 2013
·
doi:10.1093/mutage/ges080
Detection of Human Endogenous Retrovirus K (HERV-K) Transcripts in Human Prostate Cancer Cell Lines
Lorenzo Agoni, Chandan Guha, Jack Lenz
Frontiers in Oncology
·
01 Jan 2013
·
doi:10.3389/fonc.2013.00180
Prostate-specific antigen bounce predicts for a favorable prognosis following brachytherapy: a meta-analysis
Michael B. Bernstein, Nitin Ohri, James W. Hodge, Madhur Garg, William Bodner, Shalom Kalnicki, Adam P. Dicker, Chandan Guha
Journal of Contemporary Brachytherapy
·
01 Jan 2013
·
doi:10.5114/jcb.2013.38875
2012
Timing of postseed imaging influences rectal dose–volume parameters for cesium-131 prostate seed implants
Ravindra Yaparpalvi, Raquibul Hannan, Evan Landau, Norman Kahan, William Bodner, ..., Lloyd Minsky, Keyur J. Mehta, Madhur K. Garg, Shalom Kalnicki, Chandan Guha
Brachytherapy
·
01 Nov 2012
·
doi:10.1016/j.brachy.2011.07.004
Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice
Karin Blecher, Luis R. Martinez, Chaim Tuckman-Vernon, Parimala Nacharaju, David Schairer, ..., Joel M. Friedman, Alan Alfieri, Chandan Guha, Joshua D. Nosanchuk, Adam J. Friedman
Nanomedicine: Nanotechnology, Biology and Medicine
·
01 Nov 2012
·
doi:10.1016/j.nano.2012.02.014
Single Liver Lobe Repopulation with Wildtype Hepatocytes Using Regional Hepatic Irradiation Cures Jaundice in Gunn Rats
Hongchao Zhou, Xinyuan Dong, Rafi Kabarriti, Yong Chen, Yesim Avsar, ..., Laibin Liu, Ira J. Fox, Jayanta Roy-Chowdhury, Namita Roy-Chowdhury, Chandan Guha
PLoS ONE
·
16 Oct 2012
·
doi:10.1371/journal.pone.0046775
Neandertal and Denisovan retroviruses
Lorenzo Agoni, Aaron Golden, Chandan Guha, Jack Lenz
Current Biology
·
01 Jun 2012
·
doi:10.1016/j.cub.2012.04.049
An In Situ Autologous Tumor Vaccination with Combined Radiation Therapy and TLR9 Agonist Therapy
Huagang Zhang, Laibin Liu, Dong Yu, Ekambar R. Kandimalla, Hui Bin Sun, Sudhir Agrawal, Chandan Guha
PLoS ONE
·
30 May 2012
·
doi:10.1371/journal.pone.0038111
Combined immunotherapy with Listeria monocytogenes-based PSA vaccine and radiation therapy leads to a therapeutic response in a murine model of prostate cancer
Raquibul Hannan, Huagang Zhang, Anu Wallecha, Reshma Singh, Laibin Liu, Patrice Cohen, Alan Alfieri, John Rothman, Chandan Guha
Cancer Immunology, Immunotherapy
·
27 May 2012
·
doi:10.1007/s00262-012-1257-x
TLR9 Agonist Protects Mice from Radiation-Induced Gastrointestinal Syndrome
Subhrajit Saha, Payel Bhanja, Laibin Liu, Alan A. Alfieri, Dong Yu, Ekambar R. Kandimalla, Sudhir Agrawal, Chandan Guha
PLoS ONE
·
04 Jan 2012
·
doi:10.1371/journal.pone.0029357
Improving the Techniques for Human Hepatocyte Transplantation: Report from a Consensus Meeting in London
Juliana Puppi, Stephen C. Strom, Robin D. Hughes, Sanjay Bansal, Jose V. Castell, ..., Lola M. Reid, Jayanta Roy-Chowdhury, Etienne Sokal, Anne Weber, Anil Dhawan
Cell Transplantation
·
01 Jan 2012
·
doi:10.3727/096368911x566208
Progressive transition from pre-planned to intraoperative optimizing seed implant: post implementation analysis
Hsiang-Chi Kuo, William Bodner, Ravindra Yaparpalvi, Chandan Guha, Bhupendra M. Tolia, Keyur J. Mehta, Dennis Mah, Shalom Kalnicki
Journal of Contemporary Brachytherapy
·
01 Jan 2012
·
doi:10.5114/jcb.2012.27951
2011
Hepatic Radiation Toxicity: Avoidance and Amelioration
Chandan Guha, Brian D. Kavanagh
Seminars in Radiation Oncology
·
01 Oct 2011
·
doi:10.1016/j.semradonc.2011.05.003
Bone Marrow Stromal Cell Transplantation Mitigates Radiation-Induced Gastrointestinal Syndrome in Mice
Subhrajit Saha, Payel Bhanja, Rafi Kabarriti, Laibin Liu, Alan A. Alfieri, Chandan Guha
PLoS ONE
·
15 Sep 2011
·
doi:10.1371/journal.pone.0024072
Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes
Jianqiang Ding, Govardhana R. Yannam, Namita Roy-Chowdhury, Tunda Hidvegi, Hesham Basma, ..., Yesim Avsar, Chandan Guha, David H. Perlmutter, Ira J. Fox, Jayanta Roy-Chowdhury
Journal of Clinical Investigation
·
02 May 2011
·
doi:10.1172/jci45260
Experience of micromultileaf collimator linear accelerator based single fraction stereotactic radiosurgery: Tumor dose inhomogeneity, conformity, and dose fall off
Linda X. Hong, Madhur Garg, Patrick Lasala, Mimi Kim, Dennis Mah, ..., Ravindra Yaparpalvi, Dinesh Mynampati, Hsiang‐Chi Kuo, Chandan Guha, Shalom Kalnicki
Medical Physics
·
14 Feb 2011
·
doi:10.1118/1.3549764
Growth and Metastases of Human Lung Cancer Are Inhibited in Mouse Xenografts by a Transition State Analogue of 5′-Methylthioadenosine Phosphorylase
Indranil Basu, Joseph Locker, Maria B. Cassera, Thomas J. Belbin, Emilio F. Merino, Xinyuan Dong, Ivan Hemeon, Gary B. Evans, Chandan Guha, Vern L. Schramm
Journal of Biological Chemistry
·
01 Feb 2011
·
doi:10.1074/jbc.m110.198374
2010
Systemic administration of reovirus (Reolysin) inhibits growth of human sarcoma xenografts
Pooja Hingorani, Wendong Zhang, Juan Lin, Laibin Liu, Chandan Guha, E. Anders Kolb
Cancer
·
08 Nov 2010
·
doi:10.1002/cncr.25741
Barriers to the successful treatment of liver disease by hepatocyte transplantation
Kyle A. Soltys, Alejandro Soto-Gutiérrez, Masaki Nagaya, Kevin M. Baskin, Melvin Deutsch, ..., Chandan Guha, Jayanta Roy-Chowdhury, Stephen C. Strom, Jeffrey L. Platt, Ira J. Fox
Journal of Hepatology
·
01 Oct 2010
·
doi:10.1016/j.jhep.2010.05.010
Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors?
Hsiang-Chi Kuo, Wen-Shan Liu, Andrew Wu, Dennis Mah, Keh-Shih Chuang, Linda Hong, Ravi Yaparpalvi, Chandan Guha, Shalom Kalnicki
Radiation Oncology
·
03 Jun 2010
·
doi:10.1186/1748-717x-5-48
2009
Obtaining Normal Tissue Constraints Using Intensity Modulated Radiotherapy (IMRT) in Patients with Oral Cavity, Oropharnygeal, and Laryngeal Carcinoma
William K.J. Skinner, Evan D. Muse, Ravindra Yaparpalvi, Chandan Guha, Madhur K. Garg, Shalom Kalnicki
Medical Dosimetry
·
01 Dec 2009
·
doi:10.1016/j.meddos.2008.11.001
Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice
Payel Bhanja, Subhrajit Saha, Rafi Kabarriti, Laibin Liu, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury, Rani S. Sellers, Alan A. Alfieri, Chandan Guha
PLoS ONE
·
24 Nov 2009
·
doi:10.1371/journal.pone.0008014
Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon #
Xia Wang, Debi P. Sarkar, Prashant Mani, Clifford J. Steer, Yong Chen, ..., Voshavar Chandrasekhar, Arabinda Chaudhuri, Namita Roy-Chowdhury, Betsy T. Kren, Jayanta Roy-Chowdhury
Hepatology
·
01 Sep 2009
·
doi:10.1002/hep.23060
Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation†
Kosho Yamanouchi, Hongchao Zhou, Namita Roy‐Chowdhury, Frank Macaluso, Liping Liu, ..., Anthony B. Adelson, Jeffrey L. Platt, Ira J. Fox, Jayanta Roy‐Chowdhury, Chandan Guha
Hepatology
·
01 Jan 2009
·
doi:10.1002/hep.22573
2008
ICRU reference dose in an era of intensity-modulated radiation therapy clinical trials: Correlation with planning target volume mean dose and suitability for intensity-modulated radiation therapy dose prescription
Ravindra Yaparpalvi, Linda Hong, Dennis Mah, Jin Shen, Subhakar Mutyala, Marnee Spierer, Madhur Garg, Chandan Guha, Shalom Kalnicki
Radiotherapy and Oncology
·
01 Dec 2008
·
doi:10.1016/j.radonc.2008.07.025
Hyperthermia on immune regulation: A temperature’s story
Hua-Gang Zhang, Keyur Mehta, Patrice Cohen, Chandan Guha
Cancer Letters
·
01 Nov 2008
·
doi:10.1016/j.canlet.2008.05.026
Transition state analogues in quorum sensing and SAM recycling
V. L. Schramm, J. A. Gutierrez, G. Cordovano, I. Basu, C. Guha, T. J. Belbin, G. B. Evans, P. C. Tyler, R. H. Furneaux
Nucleic Acids Symposium Series
·
01 Sep 2008
·
doi:10.1093/nass/nrn038
Conformal radiotherapy for hepatocellular carcinoma
R.V. Tse, Chandan Guha, L.A. Dawson
Critical Reviews in Oncology/Hematology
·
01 Aug 2008
·
doi:10.1016/j.critrevonc.2008.01.005
Hepatic repopulation with stably transduced conditionally immortalized hepatocytes in the Gunn rat
Yujo Kawashita, Chandan Guha, Rituparna Moitra, Xia Wang, Ira J. Fox, Jayanta Roy-Chowdhury, Namita Roy-Chowdhury
Journal of Hepatology
·
01 Jul 2008
·
doi:10.1016/j.jhep.2008.02.020
Correction of Hyperoxaluria by Liver Repopulation With Hepatocytes in a Mouse Model of Primary Hyperoxaluria Type-1
Jinlan Jiang, Eduardo C. Salido, Chandan Guha, Xia Wang, Rituparna Moitra, Laibin Liu, Jayanta Roy-Chowdhury, Namita Roy-Chowdhury
Transplantation
·
15 May 2008
·
doi:10.1097/tp.0b013e31816de49e
Tumor Biology-Guided Radiotherapy Treatment Planning: Gross Tumor Volume Versus Functional Tumor Volume
Chandan Guha, Alan Alfieri, M. Donald Blaufox, Shalom Kalnicki
Seminars in Nuclear Medicine
·
01 Mar 2008
·
doi:10.1053/j.semnuclmed.2007.12.001
Hepatocellular Carcinoma: Radiation Therapy
Laura A. Dawson, Chandan Guha
The Cancer Journal
·
01 Mar 2008
·
doi:10.1097/ppo.0b013e31816a0e80
Identification of adult hepatic progenitor cells capable of repopulating injured rat liver
Mladen I. Yovchev, Petar N. Grozdanov, Hongchao Zhou, Harini Racherla, Chandan Guha, Mariana D. Dabeva
Hepatology
·
01 Feb 2008
·
doi:10.1002/hep.22047
2007
Localized Hyperthermia Combined with Intratumoral Dendritic Cells Induces Systemic Antitumor Immunity
Arunika Mukhopadhaya, Joseph Mendecki, Xinyuan Dong, Laibin Liu, Shalom Kalnicki, Madhur Garg, Alan Alfieri, Chandan Guha
Cancer Research
·
15 Aug 2007
·
doi:10.1158/0008-5472.can-07-0203
A Transition State Analogue of 5′-Methylthioadenosine Phosphorylase Induces Apoptosis in Head and Neck Cancers
Indranil Basu, Grace Cordovano, Ishita Das, Thomas J. Belbin, Chandan Guha, Vern L. Schramm
Journal of Biological Chemistry
·
01 Jul 2007
·
doi:10.1074/jbc.m702287200
Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells
Elena V. Mashalova, Chandan Guha, Namita Roy-Chowdhury, Laibin Liu, Ira J. Fox, Jayanta Roy-Chowdhury, Marshall S. Horwitz
Hepatology
·
01 Mar 2007
·
doi:10.1002/hep.21525
2006
Noninvasive evaluation of liver repopulation by transplanted hepatocytes using 31P MRS imaging in mice
Charles S. Landis, Kosho Yamanouchi, Hongchao Zhou, Sankar Mohan, Namita Roy-Chowdhury, David A. Shafritz, Alan Koretsky, Jayanta Roy-Chowdhury, Hoby P. Hetherington, Chandan Guha
Hepatology
·
01 Nov 2006
·
doi:10.1002/hep.21382
Flt3L Therapy following Localized Tumor Irradiation Generates Long-Term Protective Immune Response in Metastatic Lung Cancer: Its Implication in Designing a Vaccination Strategy
Prabir K. Chakravarty, Chandan Guha, Alan Alfieri, Vivek Beri, Zoya Niazova, Niloy J. Deb, Zuoheng Fan, Elaine K. Thomas, Bhadrasain Vikram
Oncology
·
01 Jan 2006
·
doi:10.1159/000096288
2005
Role of cysteine residues in the function of human UDP glucuronosyltransferase isoform 1A1 (UGT1A1)
Siddhartha S. Ghosh, Yang Lu, Sung W. Lee, Xia Wang, Chandan Guha, Jayanta Roy-Chowdhury, Namita Roy-Chowdhury
Biochemical Journal
·
06 Dec 2005
·
doi:10.1042/bj20050381
Liver Repopulation: A New Concept of Hepatocyte Transplantation
Yujo Kawashita, Chandan Guha, Kosho Yamanouchi, Yuichiro Ito, Yukio Kamohara, Takashi Kanematsu
Surgery Today
·
24 Aug 2005
·
doi:10.1007/s00595-005-3024-5
Cell Culture Models and Animal Models of Viral Hepatitis. Part II: Hepatitis C
Chandan Guha, Sung-W Lee, Namita Roy Chowdhury, Jayanta Roy Chowdhury
Lab Animal
·
01 Feb 2005
·
doi:10.1038/laban0205-39
Feasibility of Hepatocyte Transplantation-Based Therapies for Primary Hyperoxalurias
Chandan Guha, Kosho Yamanouchi, Jinlan Jiang, Xia Wang, Namita Roy Chowdhury, Alfredo Santana, Lawrence J. Shapiro, Eduardo Salido, Jayanta Roy-Chowdhury
American Journal of Nephrology
·
01 Jan 2005
·
doi:10.1159/000085408
2004
Bone Marrow Progenitors Are Not the Source of Expanding Oval Cells in Injured Liver
Anuradha Menthena, Niloyjyoti Deb, Michael Oertel, Petar N. Grozdanov, Jaswinder Sandhu, Shalin Shah, Chandan Guha, David A. Shafritz, Mariana D. Dabeva
STEM CELLS
·
01 Nov 2004
·
doi:10.1634/stemcells.22-6-1049
Cell Culture and Animal Models of Viral Hepatitis. Part I: Hepatitis B
Chandan Guha, Sankar Mohan, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury
Lab Animal
·
01 Jul 2004
·
doi:10.1038/laban0704-37
TNFerade Biologic, an Adenovector With a Radiation-Inducible Promoter, Carrying the Human Tumor Necrosis Factor Alpha Gene: A Phase I Study in Patients With Solid Tumors
Neil Senzer, Sridhar Mani, Alexander Rosemurgy, John Nemunaitis, Casey Cunningham, ..., Camilla Rasmussen, Henrik Rasmussen, Donald Kufe, Ralph Weichselbaum, Nader Hanna
Journal of Clinical Oncology
·
15 Feb 2004
·
doi:10.1200/jco.2004.01.227
2003
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization
Puneeth Iyengar, Terry P Combs, Shalin J Shah, Valérie Gouon-Evans, Jeffrey W Pollard, ..., Martin P Tenniswood, Chandan Guha, Michael P Lisanti, Richard G Pestell, Philipp E Scherer
Oncogene
·
25 Sep 2003
·
doi:10.1038/sj.onc.1206737
Patterns of failure after the multimodality treatment of uterine papillary serous carcinoma
Brij M. Sood, Joan Jones, Sajel Gupta, Dineo Khabele, Chandan Guha, Carol Runowicz, Gary Goldberg, Abbie Fields, Patrick Anderson, B. Vikram
International Journal of Radiation Oncology*Biology*Physics
·
01 Sep 2003
·
doi:10.1016/s0360-3016(03)00531-5
Molecular Therapies for Viral Hepatitis
Chandan Guha, Shalin J. Shah, Siddhartha S. Ghosh, Sung W. Lee, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury
BioDrugs
·
01 Jan 2003
·
doi:10.2165/00063030-200317020-00001
2002
Predictive value of linear-quadratic model in the treatment of cervical cancer using high-dose-rate brachytherapy
Brij Sood, Madhur Garg, Jai Avadhani, Giridhar Gorla, Harish Malhotra, Chandan Guha, Shivaji Deore, Bhadrasain Vikram
International Journal of Radiation Oncology*Biology*Physics
·
01 Dec 2002
·
doi:10.1016/s0360-3016(02)03051-1
Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection
Chandan Guha, Bhupesh Parashar, Niloy J. Deb, Madhur Garg, Giridhar R. Gorla, Anupam Singh, Namita Roy-Chowdhury, Bhadrasain Vikram, Jayanta Roy-Chowdhury
Hepatology
·
01 Aug 2002
·
doi:10.1053/jhep.2002.34516
Angiostatin Inhibits and Regresses Corneal Neovascularization
Balamurali K. Ambati
Archives of Ophthalmology
·
01 Aug 2002
·
doi:10.1001/archopht.120.8.1063
A long-awaited small animal model for hepatitis C
Chandan Guha, Jayanta Roy Chowdhury
Journal of Hepatology
·
01 Mar 2002
·
doi:10.1016/s0168-8278(02)00027-2