Research
Our lab focuses on radiation biology and tumor immunology with the goal of improving outcomes for cancer patients. We work with the full range of ionizing and non-ionizing forms of radiation, including low-intensity focused ultrasound (LOFU), photons, protons, and heavy ion radiation.
Highlighted
Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation
Cancer Research
·
03 Aug 2022
·
doi:10.1158/0008-5472.can-22-0656
Whole abdominal pencil beam scanned proton FLASH increases acute lethality
International Journal of Radiation Oncology*Biology*Physics
·
01 Sep 2024
·
doi:10.1016/j.ijrobp.2024.09.006
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
Stem Cell Research & Therapy
·
29 Apr 2024
·
doi:10.1186/s13287-024-03734-z
Our Published Works
2024
Whole abdominal pencil beam scanned proton FLASH increases acute lethality
International Journal of Radiation Oncology*Biology*Physics
·
01 Sep 2024
·
doi:10.1016/j.ijrobp.2024.09.006
FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone
Cold Spring Harbor Laboratory
·
11 Jul 2024
·
doi:10.1101/2024.07.08.602528
Optimizing GRID and Lattice Spatially Fractionated Radiation Therapy: Innovative Strategies for Radioresistant and Bulky Tumor Management
Seminars in Radiation Oncology
·
01 Jul 2024
·
doi:10.1016/j.semradonc.2024.05.002
Novel time-synchronized immune-guided partial tumor irradiation: Proof of principle trial
Radiotherapy and Oncology
·
01 Jul 2024
·
doi:10.1016/j.radonc.2024.110442
Innovations in Physics, Biology and Clinical Translation of Spatially Fractionated and FLASH Radiotherapy
Seminars in Radiation Oncology
·
01 Jul 2024
·
doi:10.1016/j.semradonc.2024.05.005
Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury
Cell
·
01 Jun 2024
·
doi:10.1016/j.cell.2024.05.004
Validation and reproducibility of in vivo dosimetry for pencil beam scanned FLASH proton treatment in mice
Radiotherapy and Oncology
·
01 Jun 2024
·
doi:10.1016/j.radonc.2024.110404
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
Stem Cell Research & Therapy
·
29 Apr 2024
·
doi:10.1186/s13287-024-03734-z
Synergizing radiation therapy and immunotherapy for curing incurable cancers. Opportunities and challenges.
Oncology (Williston Park, N.Y.)
·
03 Mar 2024
·
pmid:18777956
5th International Symposium on Focused Ultrasound : North Bethesda, MD, USA. 28 August- 1 September 2016
Journal of therapeutic ultrasound
·
03 Mar 2024
·
pmc:PMC5123388
Defining Minimum Treatment Parameters of Ablative Radiation Therapy in Patients With Hepatocellular Carcinoma: An Expert Consensus
Practical Radiation Oncology
·
01 Mar 2024
·
doi:10.1016/j.prro.2023.08.016
Selective Personalized RadioImmunotherapy for Locally Advanced Non–Small-Cell Lung Cancer Trial (SPRINT)
Journal of Clinical Oncology
·
10 Feb 2024
·
doi:10.1200/jco.23.00627
The potential role of precision medicine to alleviate racial disparities in prostate, bladder and renal urological cancer care
BJUI Compass
·
08 Feb 2024
·
doi:10.1002/bco2.323
Characterization of a Diverse Set of Conditionally Reprogrammed Head and Neck Cancer Cell Cultures
The Laryngoscope
·
30 Jan 2024
·
doi:10.1002/lary.31236
Patterns of presentation and delivery of care of appendiceal neoplasms in the largest municipal health care delivery system in the United States.
Journal of Clinical Oncology
·
20 Jan 2024
·
doi:10.1200/jco.2024.42.3_suppl.14
Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration
Cellular and Molecular Gastroenterology and Hepatology
·
01 Jan 2024
·
doi:10.1016/j.jcmgh.2023.10.007
2023
Haematopoietic stem cell numbers are not solely determined by niche availability
Cold Spring Harbor Laboratory
·
29 Oct 2023
·
doi:10.1101/2023.10.28.564559
PEGylated thrombopoietin mimetic, JNJ‑26366821 a novel prophylactic radiation countermeasure for acute radiation injury
Scientific Reports
·
14 Sep 2023
·
doi:10.1038/s41598-023-42443-0
Enhancing Immunogenicity in Metastatic Melanoma: Adjuvant Therapies to Promote the Anti-Tumor Immune Response
Biomedicines
·
10 Aug 2023
·
doi:10.3390/biomedicines11082245
Updates on radiotherapy-immunotherapy combinations: Proceedings of 6
th
annual ImmunoRad conference
OncoImmunology
·
21 Jun 2023
·
doi:10.1080/2162402x.2023.2222560
The role of histone H3 lysine demethylases in glioblastoma
Cancer and Metastasis Reviews
·
01 Jun 2023
·
doi:10.1007/s10555-023-10114-1
Commissioning a 250 MeV research beamline for proton FLASH radiotherapy preclinical experiments
Medical Physics
·
29 Mar 2023
·
doi:10.1002/mp.16364
CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma
Cancers
·
28 Mar 2023
·
doi:10.3390/cancers15072005
Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human α1-antitrypsin deficiency
Hepatology Communications
·
27 Feb 2023
·
doi:10.1097/hc9.0000000000000070
Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
Scientific Reports
·
04 Feb 2023
·
doi:10.1038/s41598-022-21726-y
Establishment of a diverse head and neck squamous cancer cell bank using conditional reprogramming culture methods
Journal of Medical Virology
·
10 Jan 2023
·
doi:10.1002/jmv.28388
Enhanced Glycolysis Confers Resistance Against Photon but Not Carbon Ion Irradiation in Human Glioma Cell Lines
Cancer Management and Research
·
01 Jan 2023
·
doi:10.2147/cmar.s385968
2022
Carbon Ion Irradiation Downregulates Notch Signaling in Glioma Cell Lines, Impacting Cell Migration and Spheroid Formation
Cells
·
24 Oct 2022
·
doi:10.3390/cells11213354
Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease
Frontiers in Oncology
·
06 Sep 2022
·
doi:10.3389/fonc.2022.969429
Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation
Cancer Research
·
03 Aug 2022
·
doi:10.1158/0008-5472.can-22-0656
Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
Research Square Platform LLC
·
17 Jun 2022
·
doi:10.21203/rs.3.rs-1733631/v1
Using quantitative immunohistochemistry in patients at high risk for hepatocellular cancer
Genes & Cancer
·
06 Jun 2022
·
doi:10.18632/genesandcancer.220
Improving Adjuvant Liver-Directed Treatment Recommendations for Unresectable Hepatocellular Carcinoma: An Artificial Intelligence–Based Decision-Making Tool
JCO Clinical Cancer Informatics
·
01 Jun 2022
·
doi:10.1200/cci.22.00024
Mitigation of total body irradiation-induced mortality and hematopoietic injury of mice by a thrombopoietin mimetic (JNJ-26366821)
Scientific Reports
·
03 Mar 2022
·
doi:10.1038/s41598-022-07426-7
Longitudinal Preclinical Imaging Characterizes Extracellular Drug Accumulation After Radiation Therapy in the Healthy and Leukemic Bone Marrow Vascular Microenvironment
International Journal of Radiation Oncology*Biology*Physics
·
01 Mar 2022
·
doi:10.1016/j.ijrobp.2021.10.146
A positron emission tomography radiomic signature for distant metastases risk in oropharyngeal cancer patients treated with definitive chemoradiotherapy
Physics and Imaging in Radiation Oncology
·
01 Jan 2022
·
doi:10.1016/j.phro.2022.02.005
2021
Genome-wide host methylation profiling of anal and cervical carcinoma
PLOS ONE
·
09 Dec 2021
·
doi:10.1371/journal.pone.0260857
Using Statistical Measures and Density Maps Generated From Chest Computed Tomography Scans to Identify and Monitor COVID-19 Cases in Radiation Oncology Rapidly
Cureus
·
25 Aug 2021
·
doi:10.7759/cureus.17432
Normal Tissue Injury Induced by Photon and Proton Therapies: Gaps and Opportunities
International Journal of Radiation Oncology*Biology*Physics
·
01 Aug 2021
·
doi:10.1016/j.ijrobp.2021.02.043
Extracellular Vesicles for the Treatment of Radiation Injuries
Frontiers in Pharmacology
·
18 May 2021
·
doi:10.3389/fphar.2021.662437
Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities
International Journal of Radiation Oncology*Biology*Physics
·
01 May 2021
·
doi:10.1016/j.ijrobp.2019.02.046
The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies
Frontiers in Cell and Developmental Biology
·
22 Apr 2021
·
doi:10.3389/fcell.2021.650772
Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?
Journal for ImmunoTherapy of Cancer
·
01 Apr 2021
·
doi:10.1136/jitc-2020-002038
Using CT-guided stereotactic prostate radiation therapy (CT-SPRT) to assess sustained murine prostate ablation
Scientific Reports
·
22 Mar 2021
·
doi:10.1038/s41598-021-86067-8
Who Benefits the Most From Adjuvant Durvalumab After Chemoradiotherapy for Non-small Cell Lung Cancer? An Exploratory Analysis
Practical Radiation Oncology
·
01 Mar 2021
·
doi:10.1016/j.prro.2020.09.010
Carbon ion triggered immunogenic necroptosis of nasopharyngeal carcinoma cells involving necroptotic inhibitor BCL-x
Journal of Cancer
·
01 Jan 2021
·
doi:10.7150/jca.46316
2020
Association of Addition of Ablative Therapy Following Transarterial Chemoembolization With Survival Rates in Patients With Hepatocellular Carcinoma
JAMA Network Open
·
05 Nov 2020
·
doi:10.1001/jamanetworkopen.2020.23942
The Technical and Clinical Implementation of LATTICE Radiation Therapy (LRT)
Radiation Research
·
16 Oct 2020
·
doi:10.1667/rade-20-00066.1
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Radiation Research
·
12 Oct 2020
·
doi:10.1667/rade-20-00211.1
Association of Race and Ethnicity With Comorbidities and Survival Among Patients With COVID-19 at an Urban Medical Center in New York
JAMA Network Open
·
25 Sep 2020
·
doi:10.1001/jamanetworkopen.2020.19795
Plasma metabolomic profiles in liver cancer patients following stereotactic body radiotherapy
eBioMedicine
·
01 Sep 2020
·
doi:10.1016/j.ebiom.2020.102973
Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome
Stem Cell Research & Therapy
·
27 Aug 2020
·
doi:10.1186/s13287-020-01887-1
Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy
International Journal of Radiation Oncology*Biology*Physics
·
01 Jul 2020
·
doi:10.1016/j.ijrobp.2020.03.028
Extent of Prior Lung Irradiation and Mortality in COVID-19 Patients With a Cancer History
Advances in Radiation Oncology
·
01 Jul 2020
·
doi:10.1016/j.adro.2020.04.028
Reply to Chowdhary et al
Advances in Radiation Oncology
·
01 Jul 2020
·
doi:10.1016/j.adro.2020.06.020
The thrombopoietin mimetic JNJ-26366821 increases megakaryopoiesis without affecting malignant myeloid proliferation
Leukemia & Lymphoma
·
24 Jun 2020
·
doi:10.1080/10428194.2020.1775213
Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex
PLOS ONE
·
04 Jun 2020
·
doi:10.1371/journal.pone.0233578
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression
Developmental Cell
·
01 Jun 2020
·
doi:10.1016/j.devcel.2020.04.012
Evaluating dosimetric constraints for carbon ion radiotherapy in the treatment of locally advanced pancreatic cancer
Radiation Oncology
·
07 May 2020
·
doi:10.1186/s13014-020-01515-5
Trials and Tribulations of Radio-Immuno-Oncology
Seminars in Radiation Oncology
·
01 Apr 2020
·
doi:10.1016/j.semradonc.2020.01.001
Lymphocyte-Sparing Radiotherapy: The Rationale for Protecting Lymphocyte-rich Organs When Combining Radiotherapy With Immunotherapy
Seminars in Radiation Oncology
·
01 Apr 2020
·
doi:10.1016/j.semradonc.2019.12.003
Evaluating Dosimetric Constraints for Carbon Ion Radiotherapy in the Treatment of Locally Advanced Pancreatic Cancer
Research Square Platform LLC
·
17 Mar 2020
·
doi:10.21203/rs.2.23301/v3
Postablation Modulation after Single High-Dose Radiation Therapy Improves Tumor Control via Enhanced Immunomodulation
Clinical Cancer Research
·
14 Feb 2020
·
doi:10.1158/1078-0432.ccr-18-3518
Circulating microRNAs as Biomarkers of Radiation Exposure: A Systematic Review and Meta-Analysis
International Journal of Radiation Oncology*Biology*Physics
·
01 Feb 2020
·
doi:10.1016/j.ijrobp.2019.10.028
Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity
Theranostics
·
01 Jan 2020
·
doi:10.7150/thno.42243
2019
Use of organoids to study regenerative responses to intestinal damage
American Journal of Physiology-Gastrointestinal and Liver Physiology
·
01 Dec 2019
·
doi:10.1152/ajpgi.00346.2018
In-situ vaccination using focused ultrasound heating and anti-CD-40 agonistic antibody enhances T-cell mediated local and abscopal effects in murine melanoma
International Journal of Hyperthermia
·
29 Nov 2019
·
doi:10.1080/02656736.2019.1663280
Non-Invasive Targeted Hepatic Irradiation and SPECT/CT Functional Imaging to Study Radiation-Induced Liver Damage in Small Animal Models
Cancers
·
15 Nov 2019
·
doi:10.3390/cancers11111796
Correction: Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma
Cancer Research
·
15 Nov 2019
·
doi:10.1158/0008-5472.can-19-2958
Daily Step Counts: A New Prognostic Factor in Locally Advanced Non-Small Cell Lung Cancer?
International Journal of Radiation Oncology*Biology*Physics
·
01 Nov 2019
·
doi:10.1016/j.ijrobp.2019.07.055
Comparing outcomes following total neoadjuvant therapy and following neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancer
EClinicalMedicine
·
01 Nov 2019
·
doi:10.1016/j.eclinm.2019.09.009
Low Intensity Focused Ultrasound (LOFU)-mediated Acoustic Immune Priming and Ablative Radiation Therapy for in situ Tumor Vaccines
Scientific Reports
·
29 Oct 2019
·
doi:10.1038/s41598-019-51332-4
Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma
Cancer Research
·
01 Sep 2019
·
doi:10.1158/0008-5472.can-19-0803
Association between neutrophil–lymphocyte ratio, socioeconomic status, and ethnic minority with treatment outcome in hepatocellular carcinoma
Hepatology International
·
01 Aug 2019
·
doi:10.1007/s12072-019-09965-0
Human papillomavirus, radiation dose and survival of patients with anal cancer
Acta Oncologica
·
08 Jul 2019
·
doi:10.1080/0284186x.2019.1634834
A Quantitative Clinical Decision–Support Strategy Identifying Which Patients With Oropharyngeal Head and Neck Cancer May Benefit the Most From Proton Radiation Therapy
International Journal of Radiation Oncology*Biology*Physics
·
01 Jul 2019
·
doi:10.1016/j.ijrobp.2018.11.039
Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis
Journal of Hepatology
·
01 Jun 2019
·
doi:10.1016/j.jhep.2019.01.010
Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate
Stem Cell Reports
·
01 Jun 2019
·
doi:10.1016/j.stemcr.2019.04.019
Centers with more therapeutic modalities are associated with improved outcomes for patients with hepatocellular carcinoma
Journal of Gastrointestinal Oncology
·
01 Jun 2019
·
doi:10.21037/jgo.2019.01.30
Hepatocyte Transplantation: Quo Vadis?
International Journal of Radiation Oncology*Biology*Physics
·
01 Mar 2019
·
doi:10.1016/j.ijrobp.2018.11.016
BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice
Gastroenterology
·
01 Mar 2019
·
doi:10.1053/j.gastro.2018.11.024
Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1
Oncotarget
·
11 Jan 2019
·
doi:10.18632/oncotarget.26563
Origin of Locoregional Recurrences After Definitive Intensity-modulated Radiation Therapy (IMRT) for Laryngeal Cancer Determined Based on Follow-up PET/CT Imaging
Cureus
·
08 Jan 2019
·
doi:10.7759/cureus.3856
2018
Radiation therapy for patients with newly diagnosed metastatic head and neck squamous cell carcinoma
Head & Neck
·
16 Dec 2018
·
doi:10.1002/hed.25476
Model for End-Stage Liver Disease and Sodium Velocity Predicts Overall Survival in Nonmetastatic Hepatocellular Carcinoma Patients
Canadian Journal of Gastroenterology and Hepatology
·
07 Nov 2018
·
doi:10.1155/2018/5681979
Utilization of Transoral Robotic Surgery (TORS) in patients with Oropharyngeal Squamous Cell Carcinoma and its impact on survival and use of chemotherapy
Oral Oncology
·
01 Nov 2018
·
doi:10.1016/j.oraloncology.2018.06.009
Radiofrequency Ablation Versus Stereotactic Body Radiotherapy for Hepatocellular Carcinoma: Caution When Interpreting Observational Data
Journal of Clinical Oncology
·
20 Aug 2018
·
doi:10.1200/jco.2018.78.0122
Therapeutic potential of adenovirus-mediated TFF2-CTP-Flag peptide for treatment of colorectal cancer
Cancer Gene Therapy
·
25 Jul 2018
·
doi:10.1038/s41417-018-0036-z
Systematic Review of Normal Tissue Complication Models Relevant to Standard Fractionation Radiation Therapy of the Head and Neck Region Published After the QUANTEC Reports
International Journal of Radiation Oncology*Biology*Physics
·
01 Feb 2018
·
doi:10.1016/j.ijrobp.2017.09.041
2017
Expression of the DNA repair gene MLH1 correlates with survival in patients who have resected pancreatic cancer and have received adjuvant chemoradiation: NRG Oncology RTOG Study 9704
Cancer
·
20 Oct 2017
·
doi:10.1002/cncr.31058
Host conditioning and rejection monitoring in hepatocyte transplantation in humans
Journal of Hepatology
·
01 May 2017
·
doi:10.1016/j.jhep.2016.12.017
MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa
Oncotarget
·
06 Apr 2017
·
doi:10.18632/oncotarget.16886
Continuous Activity Monitoring During Concurrent Chemoradiotherapy
International Journal of Radiation Oncology*Biology*Physics
·
01 Apr 2017
·
doi:10.1016/j.ijrobp.2016.12.030
Significance of Co-expression of Epidermal Growth Factor Receptor and Ki67 on Clinical Outcome in Patients With Anal Cancer Treated With Chemoradiotherapy: An Analysis of NRG Oncology RTOG 9811
International Journal of Radiation Oncology*Biology*Physics
·
01 Mar 2017
·
doi:10.1016/j.ijrobp.2016.11.021
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy
EBioMedicine
·
01 Mar 2017
·
doi:10.1016/j.ebiom.2017.02.004
Evolutionarily conserved serum microRNAs predict radiation-induced fatality in nonhuman primates
Science Translational Medicine
·
01 Mar 2017
·
doi:10.1126/scitranslmed.aal2408
A Model for Precise and Uniform Pelvic- and Limb-Sparing Abdominal Irradiation to Study the Radiation-Induced Gastrointestinal Syndrome in Mice Using Small Animal Irradiation Systems
Dose-Response
·
04 Jan 2017
·
doi:10.1177/1559325816685798
2016
Human Urinary Epithelial Cells as a Source of Engraftable Hepatocyte-Like Cells Using Stem Cell Technology
Cell Transplantation
·
01 Dec 2016
·
doi:10.3727/096368916x692014
Gunn Rats as a Surrogate Model for Evaluation of Hepatocyte Transplantation-Based Therapies of Crigler–Najjar Syndrome Type 1
Methods in Molecular Biology
·
10 Nov 2016
·
doi:10.1007/978-1-4939-6506-9_9
Identifying Urinary and Serum Exosome Biomarkers for Radiation Exposure Using a Data Dependent Acquisition and SWATH-MS Combined Workflow
International Journal of Radiation Oncology*Biology*Physics
·
01 Nov 2016
·
doi:10.1016/j.ijrobp.2016.06.008
Precision Medicine and Pancreatic Cancer
Pancreas
·
01 Nov 2016
·
doi:10.1097/mpa.0000000000000710
Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
Nature Communications
·
13 Oct 2016
·
doi:10.1038/ncomms13096
Targeted Therapy for Hepatocellular Carcinoma
Seminars in Radiation Oncology
·
01 Oct 2016
·
doi:10.1016/j.semradonc.2016.06.004
Stromal Progenitor Cells in Mitigation of Non-hematopoietic Radiation Injuries
Current Pathobiology Reports
·
07 Sep 2016
·
doi:10.1007/s40139-016-0114-6
Hepatocyte-like cells derived from induced pluripotent stem cells
Hepatology International
·
17 Aug 2016
·
doi:10.1007/s12072-016-9757-y
Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia
Cancer Research
·
14 Aug 2016
·
doi:10.1158/0008-5472.can-15-3062
Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study
Journal of the National Cancer Institute
·
04 Jul 2016
·
doi:10.1093/jnci/djw133
Radiation Therapy Noncompliance and Clinical Outcomes in an Urban Academic Cancer Center
International Journal of Radiation Oncology*Biology*Physics
·
01 Jun 2016
·
doi:10.1016/j.ijrobp.2016.01.043
Tumor Cells Surviving Exposure to Proton or Photon Radiation Share a Common Immunogenic Modulation Signature, Rendering Them More Sensitive to T Cell–Mediated Killing
International Journal of Radiation Oncology*Biology*Physics
·
01 May 2016
·
doi:10.1016/j.ijrobp.2016.02.022
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling
Cell
·
01 Apr 2016
·
doi:10.1016/j.cell.2016.03.045
RECQ1 A159C Polymorphism Is Associated With Overall Survival of Patients With Resected Pancreatic Cancer: A Replication Study in NRG Oncology Radiation Therapy Oncology Group 9704
International Journal of Radiation Oncology*Biology*Physics
·
01 Mar 2016
·
doi:10.1016/j.ijrobp.2015.10.062
Do changes in interfraction organ at risk volume and cylinder insertion geometry impact delivered dose in high-dose-rate vaginal cuff brachytherapy?
Brachytherapy
·
01 Mar 2016
·
doi:10.1016/j.brachy.2015.11.004
In Vitro Photoirradiation System for Simultaneous Irradiation with Different Light Doses at a Fixed Temperature
Photomedicine and Laser Surgery
·
01 Mar 2016
·
doi:10.1089/pho.2015.4030
Management algorithm for HIV-associated parotid lymphoepithelial cysts
European Archives of Oto-Rhino-Laryngology
·
16 Feb 2016
·
doi:10.1007/s00405-016-3926-4
Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T Cell Tolerance and Prevents Immune Escape
The Journal of Immunology
·
15 Feb 2016
·
doi:10.4049/jimmunol.1500541
A simple method for determining the coagulation threshold temperature of transparent tissue‐mimicking thermal therapy gel phantoms: Validated by magnetic resonance imaging thermometry
Medical Physics
·
08 Feb 2016
·
doi:10.1118/1.4941361
Dosimetry Formalism and Implementation of a Homogenous Irradiation Protocol to Improve the Accuracy of Small Animal Whole-Body Irradiation Using a 137Cs Irradiator
Health Physics
·
01 Feb 2016
·
doi:10.1097/hp.0000000000000462
Hippocampal-dependent neurocognitive impairment following cranial irradiation observed in pre-clinical models: current knowledge and possible future directions
The British Journal of Radiology
·
01 Jan 2016
·
doi:10.1259/bjr.20150762
2015
Glycogen Synthase Kinase 3 Beta Predicts Survival in Resected Adenocarcinoma of the Pancreas
Clinical Cancer Research
·
14 Dec 2015
·
doi:10.1158/1078-0432.ccr-15-0789
Proposal for a Simple and Efficient Monthly Quality Management Program Assessing the Consistency of Robotic Image-Guided Small Animal Radiation Systems
Health Physics
·
01 Nov 2015
·
doi:10.1097/hp.0000000000000323
In vivo1H MRS and31P MRSI of the response to cyclocreatine in transgenic mouse liver expressing creatine kinase
NMR in Biomedicine
·
09 Oct 2015
·
doi:10.1002/nbm.3391
A mouse model replicating hippocampal sparing cranial irradiation in humans: A tool for identifying new strategies to limit neurocognitive decline
Scientific Reports
·
24 Sep 2015
·
doi:10.1038/srep14384
Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes
Stem Cell Reports
·
01 Jul 2015
·
doi:10.1016/j.stemcr.2015.04.017
Are We Ready for a Radiological Terrorist Attack Yet? Report From the Centers for Medical Countermeasures Against Radiation Network
International Journal of Radiation Oncology*Biology*Physics
·
01 Jul 2015
·
doi:10.1016/j.ijrobp.2015.02.042
Investigation of the stress response to mechanical versus thermal non-ablative focused ultrasound therapy in three in vivo murine cancer models
Journal of Therapeutic Ultrasound
·
30 Jun 2015
·
doi:10.1186/2050-5736-3-s1-p71
Immunomodulation of prostate cancer cells after low energy focused ultrasound
Journal of Therapeutic Ultrasound
·
30 Jun 2015
·
doi:10.1186/2050-5736-3-s1-o63
Integrative Metabolic Signatures for Hepatic Radiation Injury
PLOS ONE
·
05 Jun 2015
·
doi:10.1371/journal.pone.0124795
Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury
Science Translational Medicine
·
13 May 2015
·
doi:10.1126/scitranslmed.aaa6593
The Triterpenoid RTA 408 is a Robust Mitigator of Hematopoietic Acute Radiation Syndrome in Mice
Radiation Research
·
01 Mar 2015
·
doi:10.1667/rr13900.1
Intestinal Microbiota-Derived Metabolomic Blood Plasma Markers for Prior Radiation Injury
International Journal of Radiation Oncology*Biology*Physics
·
01 Feb 2015
·
doi:10.1016/j.ijrobp.2014.10.023
Pre-treatment FDG-PET predicts the site of in-field progression following concurrent chemoradiotherapy for stage III non-small cell lung cancer
Lung Cancer
·
01 Jan 2015
·
doi:10.1016/j.lungcan.2014.10.016
Predictors of Radiation Therapy Noncompliance in an Urban Academic Cancer Center
International Journal of Radiation Oncology*Biology*Physics
·
01 Jan 2015
·
doi:10.1016/j.ijrobp.2014.09.030
2014
Photodynamic Therapy and Its Role in Combined Modality Anticancer Treatment
Technology in Cancer Research & Treatment
·
05 Nov 2014
·
doi:10.1177/1533034614556192
Prostate-specific antigen decline during salvage radiation therapy following prostatectomy is associated with reduced biochemical failure
Practical Radiation Oncology
·
01 Nov 2014
·
doi:10.1016/j.prro.2014.01.002
Contouring and Constraining Bowel on a Full-Bladder Computed Tomography Scan May Not Reflect Treatment Bowel Position and Dose Certainty in Gynecologic External Beam Radiation Therapy
International Journal of Radiation Oncology*Biology*Physics
·
01 Nov 2014
·
doi:10.1016/j.ijrobp.2014.07.016
An AutologousIn SituTumor Vaccination Approach for Hepatocellular Carcinoma. 1. Flt3 Ligand Gene Transfer Increases Antitumor Effects of a Radio-Inducible Suicide Gene Therapy in an Ectopic Tumor Model
Radiation Research
·
01 Aug 2014
·
doi:10.1667/rr13594.1
Immunobiology of Radiotherapy: New Paradigms
Radiation Research
·
01 Aug 2014
·
doi:10.1667/rr13849.1
Considerations for Combined Immune Checkpoint Modulation and Radiation Treatment
Radiation Research
·
01 Aug 2014
·
doi:10.1667/rr13667.1
Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects
Antioxidants & Redox Signaling
·
10 Jul 2014
·
doi:10.1089/ars.2013.5652
Bone Marrow–Derived Stromal Cell Therapy in Cirrhosis: Clinical Evidence, Cellular Mechanisms, and Implications for the Treatment of Hepatocellular Carcinoma
International Journal of Radiation Oncology*Biology*Physics
·
01 Jul 2014
·
doi:10.1016/j.ijrobp.2014.02.017
Low intensity focused ultrasound (LOFU) modulates unfolded protein response and sensitizes prostate cancer to 17AAG
Oncoscience
·
03 Jun 2014
·
doi:10.18632/oncoscience.48
Advanced mass spectrometry‐based multi‐omics technologies for exploring the pathogenesis of hepatocellular carcinoma
Mass Spectrometry Reviews
·
02 Jun 2014
·
doi:10.1002/mas.21439
Hedgehog signaling and radiation induced liver injury: a delicate balance
Hepatology International
·
08 May 2014
·
doi:10.1007/s12072-014-9532-x
Radiation-Induced Modulation of Costimulatory and Coinhibitory T-Cell Signaling Molecules on Human Prostate Carcinoma Cells Promotes Productive Antitumor Immune Interactions
Cancer Biotherapy and Radiopharmaceuticals
·
01 May 2014
·
doi:10.1089/cbr.2013.1578
Rigosertib Is a More Effective Radiosensitizer Than Cisplatin in Concurrent Chemoradiation Treatment of Cervical Carcinoma, In Vitro and In Vivo
International Journal of Radiation Oncology*Biology*Physics
·
01 Apr 2014
·
doi:10.1016/j.ijrobp.2013.12.051
Liver regeneration and energetic changes in rats following hepatic radiation therapy and hepatocyte transplantation by 31P MRSI
Liver International
·
15 Mar 2014
·
doi:10.1111/liv.12507
A Nonhuman Primate Model of Human Radiation-Induced Venocclusive Liver Disease and Hepatocyte Injury
International Journal of Radiation Oncology*Biology*Physics
·
01 Feb 2014
·
doi:10.1016/j.ijrobp.2013.10.037
Induced Pluripotent Stem Cells as a Source of Hepatocytes
Current Pathobiology Reports
·
11 Jan 2014
·
doi:10.1007/s40139-013-0039-2
Biological Effects Induced by Non-thermal Ultrasound and Implications for Cancer Therapy
Technology in Cancer Research & Treatment
·
01 Jan 2014
·
doi:10.7785/tcrt.2012.500407
2013
Construction of liver tissue in vivo with preparative partial hepatic irradiation and growth stimulus: investigations of less invasive techniques and progenitor cells
Journal of Surgical Research
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01 Dec 2013
·
doi:10.1016/j.jss.2013.06.016
Lessons Learned from Radiation Oncology Clinical Trials
Clinical Cancer Research
·
14 Nov 2013
·
doi:10.1158/1078-0432.ccr-13-1116
Endothelial cells mitigate DNA damage and promote the regeneration of hematopoietic stem cells after radiation injury
Stem Cell Research
·
01 Nov 2013
·
doi:10.1016/j.scr.2013.07.001
Harnessing the Potential of Radiation-Induced Immune Modulation for Cancer Therapy
Cancer Immunology Research
·
01 Nov 2013
·
doi:10.1158/2326-6066.cir-13-0141
Variant Splicing and Influence of Ionizing Radiation on Human Endogenous Retrovirus K (HERV-K) Transcripts in Cancer Cell Lines
PLoS ONE
·
18 Oct 2013
·
doi:10.1371/journal.pone.0076472
Combination Therapy with Local Radiofrequency Ablation and Systemic Vaccine Enhances Antitumor Immunity and Mediates Local and Distal Tumor Regression
PLoS ONE
·
24 Jul 2013
·
doi:10.1371/journal.pone.0070417
Clinical and molecular exploration of the impact of radiation therapy on Marfan syndrome patients
Practical Radiation Oncology
·
01 Jul 2013
·
doi:10.1016/j.prro.2012.07.006
Who Benefits From Adjuvant Radiation Therapy for Gastric Cancer? A Meta-Analysis
International Journal of Radiation Oncology*Biology*Physics
·
01 Jun 2013
·
doi:10.1016/j.ijrobp.2013.02.008
Effects of radiation on the epidermal growth factor receptor pathway in the heart
International Journal of Radiation Biology
·
16 Apr 2013
·
doi:10.3109/09553002.2013.782110
Opportunities and Challenges in the Era of Molecularly Targeted Agents and Radiation Therapy
JNCI: Journal of the National Cancer Institute
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15 Mar 2013
·
doi:10.1093/jnci/djt055
T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice
Mutagenesis
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05 Feb 2013
·
doi:10.1093/mutage/ges080
Detection of Human Endogenous Retrovirus K (HERV-K) Transcripts in Human Prostate Cancer Cell Lines
Frontiers in Oncology
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01 Jan 2013
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doi:10.3389/fonc.2013.00180
Prostate-specific antigen bounce predicts for a favorable prognosis following brachytherapy: a meta-analysis
Journal of Contemporary Brachytherapy
·
01 Jan 2013
·
doi:10.5114/jcb.2013.38875
2012
Timing of postseed imaging influences rectal dose–volume parameters for cesium-131 prostate seed implants
Brachytherapy
·
01 Nov 2012
·
doi:10.1016/j.brachy.2011.07.004
Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice
Nanomedicine: Nanotechnology, Biology and Medicine
·
01 Nov 2012
·
doi:10.1016/j.nano.2012.02.014
Single Liver Lobe Repopulation with Wildtype Hepatocytes Using Regional Hepatic Irradiation Cures Jaundice in Gunn Rats
PLoS ONE
·
16 Oct 2012
·
doi:10.1371/journal.pone.0046775
Neandertal and Denisovan retroviruses
Current Biology
·
01 Jun 2012
·
doi:10.1016/j.cub.2012.04.049
An In Situ Autologous Tumor Vaccination with Combined Radiation Therapy and TLR9 Agonist Therapy
PLoS ONE
·
30 May 2012
·
doi:10.1371/journal.pone.0038111
Combined immunotherapy with Listeria monocytogenes-based PSA vaccine and radiation therapy leads to a therapeutic response in a murine model of prostate cancer
Cancer Immunology, Immunotherapy
·
27 May 2012
·
doi:10.1007/s00262-012-1257-x
TLR9 Agonist Protects Mice from Radiation-Induced Gastrointestinal Syndrome
PLoS ONE
·
04 Jan 2012
·
doi:10.1371/journal.pone.0029357
Improving the Techniques for Human Hepatocyte Transplantation: Report from a Consensus Meeting in London
Cell Transplantation
·
01 Jan 2012
·
doi:10.3727/096368911x566208
Progressive transition from pre-planned to intraoperative optimizing seed implant: post implementation analysis
Journal of Contemporary Brachytherapy
·
01 Jan 2012
·
doi:10.5114/jcb.2012.27951
2011
Hepatic Radiation Toxicity: Avoidance and Amelioration
Seminars in Radiation Oncology
·
01 Oct 2011
·
doi:10.1016/j.semradonc.2011.05.003
Bone Marrow Stromal Cell Transplantation Mitigates Radiation-Induced Gastrointestinal Syndrome in Mice
PLoS ONE
·
15 Sep 2011
·
doi:10.1371/journal.pone.0024072
Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes
Journal of Clinical Investigation
·
02 May 2011
·
doi:10.1172/jci45260
Experience of micromultileaf collimator linear accelerator based single fraction stereotactic radiosurgery: Tumor dose inhomogeneity, conformity, and dose fall off
Medical Physics
·
14 Feb 2011
·
doi:10.1118/1.3549764
Growth and Metastases of Human Lung Cancer Are Inhibited in Mouse Xenografts by a Transition State Analogue of 5′-Methylthioadenosine Phosphorylase
Journal of Biological Chemistry
·
01 Feb 2011
·
doi:10.1074/jbc.m110.198374
2010
Systemic administration of reovirus (Reolysin) inhibits growth of human sarcoma xenografts
Cancer
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08 Nov 2010
·
doi:10.1002/cncr.25741
Barriers to the successful treatment of liver disease by hepatocyte transplantation
Journal of Hepatology
·
01 Oct 2010
·
doi:10.1016/j.jhep.2010.05.010
Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors?
Radiation Oncology
·
03 Jun 2010
·
doi:10.1186/1748-717x-5-48
2009
Obtaining Normal Tissue Constraints Using Intensity Modulated Radiotherapy (IMRT) in Patients with Oral Cavity, Oropharnygeal, and Laryngeal Carcinoma
Medical Dosimetry
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01 Dec 2009
·
doi:10.1016/j.meddos.2008.11.001
Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice
PLoS ONE
·
24 Nov 2009
·
doi:10.1371/journal.pone.0008014
Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon
Hepatology
·
06 May 2009
·
doi:10.1002/hep.23060
2008
ICRU reference dose in an era of intensity-modulated radiation therapy clinical trials: Correlation with planning target volume mean dose and suitability for intensity-modulated radiation therapy dose prescription
Radiotherapy and Oncology
·
01 Dec 2008
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doi:10.1016/j.radonc.2008.07.025
Hyperthermia on immune regulation: A temperature’s story
Cancer Letters
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01 Nov 2008
·
doi:10.1016/j.canlet.2008.05.026
Transition state analogues in quorum sensing and SAM recycling
Nucleic Acids Symposium Series
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01 Sep 2008
·
doi:10.1093/nass/nrn038
Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation
Hepatology
·
08 Aug 2008
·
doi:10.1002/hep.22573
Conformal radiotherapy for hepatocellular carcinoma
Critical Reviews in Oncology/Hematology
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01 Aug 2008
·
doi:10.1016/j.critrevonc.2008.01.005
Hepatic repopulation with stably transduced conditionally immortalized hepatocytes in the Gunn rat
Journal of Hepatology
·
01 Jul 2008
·
doi:10.1016/j.jhep.2008.02.020
Correction of Hyperoxaluria by Liver Repopulation With Hepatocytes in a Mouse Model of Primary Hyperoxaluria Type-1
Transplantation
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15 May 2008
·
doi:10.1097/tp.0b013e31816de49e
Tumor Biology-Guided Radiotherapy Treatment Planning: Gross Tumor Volume Versus Functional Tumor Volume
Seminars in Nuclear Medicine
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01 Mar 2008
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doi:10.1053/j.semnuclmed.2007.12.001
Hepatocellular Carcinoma: Radiation Therapy
The Cancer Journal
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01 Mar 2008
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doi:10.1097/ppo.0b013e31816a0e80
2007
Identification of adult hepatic progenitor cells capable of repopulating injured rat liver
Hepatology
·
19 Nov 2007
·
doi:10.1002/hep.22047
Localized Hyperthermia Combined with Intratumoral Dendritic Cells Induces Systemic Antitumor Immunity
Cancer Research
·
15 Aug 2007
·
doi:10.1158/0008-5472.can-07-0203
A Transition State Analogue of 5′-Methylthioadenosine Phosphorylase Induces Apoptosis in Head and Neck Cancers
Journal of Biological Chemistry
·
01 Jul 2007
·
doi:10.1074/jbc.m702287200
Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells
Hepatology
·
01 Mar 2007
·
doi:10.1002/hep.21525
2006
Flt3L Therapy following Localized Tumor Irradiation Generates Long-Term Protective Immune Response in Metastatic Lung Cancer: Its Implication in Designing a Vaccination Strategy
Oncology
·
01 Jan 2006
·
doi:10.1159/000096288
Noninvasive evaluation of liver repopulation by transplanted hepatocytes using31P MRS imaging in mice
Hepatology
·
01 Jan 2006
·
doi:10.1002/hep.21382
2005
Role of cysteine residues in the function of human UDP glucuronosyltransferase isoform 1A1 (UGT1A1)
Biochemical Journal
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06 Dec 2005
·
doi:10.1042/bj20050381
Liver Repopulation: A New Concept of Hepatocyte Transplantation
Surgery Today
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24 Aug 2005
·
doi:10.1007/s00595-005-3024-5
Cell Culture Models and Animal Models of Viral Hepatitis. Part II: Hepatitis C
Lab Animal
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01 Feb 2005
·
doi:10.1038/laban0205-39
Feasibility of Hepatocyte Transplantation-Based Therapies for Primary Hyperoxalurias
American Journal of Nephrology
·
01 Jan 2005
·
doi:10.1159/000085408
2004
Bone Marrow Progenitors Are Not the Source of Expanding Oval Cells in Injured Liver
STEM CELLS
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01 Nov 2004
·
doi:10.1634/stemcells.22-6-1049
Cell Culture and Animal Models of Viral Hepatitis. Part I: Hepatitis B
Lab Animal
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01 Jul 2004
·
doi:10.1038/laban0704-37
TNFerade Biologic, an Adenovector With a Radiation-Inducible Promoter, Carrying the Human Tumor Necrosis Factor Alpha Gene: A Phase I Study in Patients With Solid Tumors
Journal of Clinical Oncology
·
15 Feb 2004
·
doi:10.1200/jco.2004.01.227
2003
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization
Oncogene
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25 Sep 2003
·
doi:10.1038/sj.onc.1206737
Patterns of failure after the multimodality treatment of uterine papillary serous carcinoma
International Journal of Radiation Oncology*Biology*Physics
·
01 Sep 2003
·
doi:10.1016/s0360-3016(03)00531-5
Molecular Therapies for Viral Hepatitis
BioDrugs
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01 Jan 2003
·
doi:10.2165/00063030-200317020-00001
2002
Predictive value of linear-quadratic model in the treatment of cervical cancer using high-dose-rate brachytherapy
International Journal of Radiation Oncology*Biology*Physics
·
01 Dec 2002
·
doi:10.1016/s0360-3016(02)03051-1
Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection
Hepatology
·
01 Aug 2002
·
doi:10.1053/jhep.2002.34516
Angiostatin Inhibits and Regresses Corneal Neovascularization
Archives of Ophthalmology
·
01 Aug 2002
·
doi:10.1001/archopht.120.8.1063
A long-awaited small animal model for hepatitis C
Journal of Hepatology
·
01 Mar 2002
·
doi:10.1016/s0168-8278(02)00027-2